Anti-Amphoterin, Anti-High mobility group box 1, Anti-High mobility group protein 1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-HMGB1 (HMG1) (C-terminal) antibody produced in rabbit has been used in ELISA and immunofluorescence.
Allgemeine Beschreibung
The High Mobility Group (HMG1) is secreted by activated monocytes and macrophages. The gene is mapped to human chromosome 13q12.
Biochem/physiol Actions
In the nucleus, HMGB1 (high-mobility group protein B1) works as a nucleosome stabilizer and transcriptional regulator. It also exhibits chaperone-like activity and suppresses aggregation of polyglutamine. It has a role in inflammation and autophagy. HMGB1 can interact with toll-like receptor (TLR) 2 and 4, interleukin-1β, chemokine (C-X-C motif) ligand 12 (CXCL12) and pathogen-associated molecular pattern (PAMP) molecules. It also works as a damage-associated molecular pattern molecule (DAMP).
Anti-Amphoterin, Anti-High mobility group box 1, Anti-High mobility group protein 1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
