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Pilocarpinhydrochlorid

(+)-Pilocarpine hydrochloride Struktur
54-71-7
CAS-Nr.
54-71-7
Bezeichnung:
Pilocarpinhydrochlorid
Englisch Name:
(+)-Pilocarpine hydrochloride
Synonyma:
PILOCARPINE HCL;PILOCARPINE HYDROCHLORIDE;(3S,4R)-4,5-DIHYDRO-3-ETHYL-4-(1-METHYL-1H-IMIDAZOL-5-YLMETHYL)-2(3H)-FURANONE HYDROCHLORIDE;Salagen;Sanpilo;pilocar;pilocel;(3S,4R)-;Akarpine;ami-pilo
CBNumber:
CB1236112
Summenformel:
C11H17ClN2O2
Molgewicht:
244.72
MOL-Datei:
54-71-7.mol

Pilocarpinhydrochlorid Eigenschaften

Schmelzpunkt:
202-205 °C(lit.)
alpha 
89 º (C=5, H2O)
storage temp. 
2-8°C
L?slichkeit
H2O: 100 mg/mL
Aggregatzustand
powder
Farbe
white
Optische Rotation
+91.7 (H2O)
Wasserl?slichkeit
soluble
Sensitive 
Hygroscopic
Merck 
14,7424
BRN 
4034491
Stabilit?t:
Hygroscopic
Major Application
forensics and toxicology
veterinary
InChI
1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
InChIKey
RNAICSBVACLLGM-GNAZCLTHSA-N
SMILES
Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
LogP
-0.095 (est)
CAS Datenbank
54-71-7(CAS DataBase Reference)
EPA chemische Informationen
Pilocarpine monohydrochloride (54-71-7)

Sicherheit

Kennzeichnung gef?hrlicher T+,T
R-S?tze: 26/28-25-23
S-S?tze: 25-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS-Nr. TK1450000
3-8-10
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29399990
Speicherklasse 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Inhalation
Acute Tox. 2 Oral

Pilocarpinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R26/28:Sehr giftig beim Einatmen und Verschlucken.

S-S?tze Betriebsanweisung:

S25:Berührung mit den Augen vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Chemische Eigenschaften

Crystalline Solid

Verwenden

(+)-Pilocarpine hydrochloride is a muscarinic M1 and M2 acetylcholine receptor agonist with pKB values of 5 and 3.7, respectively. Systemic administration of (+)-Pilocarpine hydrochloride is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses.

Allgemeine Beschreibung

Pilocarpine monohydrochlorideis the hydrochloride of an alkaloid obtainedfrom the dried leaflets of Pilocarpus jaborandi or P. microphyllus,in which it occurs to the extent of about 0.5% togetherwith other alkaloids.

Biologische Aktivit?t

Muscarinic agonist.

Clinical Use

Pilocarpine, the salt of an alkaloid obtained from Pilocarpus jaborandi, is an example of a muscarinic agonist that does not adhere to the traditional SAR. In 1876, Langley reported that extracts containing the alkaloid stimulated the end organs of parasympathetic neurons. The structure of pilocarpine was reported in 1901.
Pilocarpine is marketed as tablets (Salogen), an ophthalmic solution, and gel. It penetrates the eye well and is the miotic of choice for open-angle glaucoma and to terminate acute angle closure attacks. It also is used for the treatment of xerostomia (dryness of the mouth) caused by radiation therapy of the head and neck, Sjogren's syndrome, or as a side effect of some psychotropic drugs.

Sicherheitsprofil

Poison by ingestion, intraperitoneal, and intravenous routes. Experimental teratogenic and reproductive effects. Human systemic effects: cardiac changes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PILOCARPINE.

Pilocarpinhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pilocarpinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 326)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Fortuna Chemical Co., Ltd
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CONIER CHEM AND PHARMA LIMITED
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54-71-7(Pilocarpinhydrochlorid)Verwandte Suche:


  • Pilocarpine HCL & Nitrate
  • PIEFELTARRAENIN IA(SH)
  • Pilocarpine Hydrochloride (200 mg)
  • Pilocarpin Hydrochloride
  • (3S,4R)-
  • PILOCARPINE HCL(P)
  • Akarpine
  • AlMocarpin
  • Pilopine VS
  • (3S,4R)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone Hydrochloride
  • Pilocarpine Chloride
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, hydrochloride (1:1), (3S,4R)-
  • NSC 5746 HCl
  • Sanpilo
  • Pilocarpal
  • Pilocarpine, monohydrochloride (8CI)
  • Pilocarpinhydrochlorid
  • ALMOCARPINE HYDROCHLORIDE
  • 3-ETHYL-4-[(1-METHYL-5-IMIDAZOLYL)METHYL]TETRAHYDROFURAN-2-ONE HYDROCHLORIDE
  • (3S-CIS)-3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2(3H)-FURANONE HYDROCHLORIDE
  • (+)-PILOCARPINE HYDROCHLORIDE
  • (3s-cis)-ochlorid
  • 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-,monohydrochloride,(3S-cis)-2(3H)-Furanone
  • 3-ethyldihydro-4-[(1-methyl-1h-imidazol-5-yl)methyl]-2(3h)-furanonmonohydr
  • almocarpine
  • ami-pilo
  • amisturap
  • isopto-carpine
  • mi-piloophthsol
  • pilocar
  • pilocarpine,monohydrochloride
  • pilocarpinemuriate
  • pilocel
  • pilomiotin
  • pilovisc
  • PILOCARPINE HCL. USP
  • PILOCARPINE HYDROCHLORIDE USP
  • (+)-Pilocarpinehydrochloride,99%
  • Pilocarpine hydrochlororide
  • 2(3H)-Furanone, 3-ethyldihydro-4-(1-methyl-1H-imidazol-5-yl)methyl-, monohydrochloride, (3S,4R)-
  • PILOCARPINEHYDROCHLORIDE,CRYSTAL,USP
  • PILOCARPINE HCL(RG)
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S,4R)- (9CI)
  • 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride, (3S-cis)-
  • Adsorbocarpine
  • NSC 5746
  • Pilocar SMP
  • Pilocarpine hydrocholoride
  • Pilocarpine-d3 HCl
  • 3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone hydrochloride
  • Pilocarpine hydrochloride CRS
  • Pilocarpine hydrochl
  • abs551003
  • Pilocarpine Hydrochloride (1538902)
  • (E)-2,3,5,4'-Tetrahydroxy stilbene-2-O-glucoside
  • 4'-Tetrahydroxystilbene 2-O-β-D-glucoside
  • 4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside
  • 5-Tetrahydroxystilbene 2-O-D-glucoside
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