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2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid

Nicardipine hydrochloride Struktur
54527-84-3
CAS-Nr.
54527-84-3
Bezeichnung:
2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid
Englisch Name:
Nicardipine hydrochloride
Synonyma:
Naratriptan HCl;NICARDIPINE HCL;YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin
CBNumber:
CB1244267
Summenformel:
C26H30ClN3O6
Molgewicht:
515.99
MOL-Datei:
54527-84-3.mol

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Eigenschaften

Schmelzpunkt:
176-1780C
storage temp. 
2-8°C
L?slichkeit
DMSO: ~1 mg/mL
Aggregatzustand
powder
Farbe
yellow
Merck 
14,6495
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month.
InChI
1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
InChIKey
AIKVCUNQWYTVTO-UHFFFAOYSA-N
SMILES
C1(C(C(=O)OC)=C(NC(C)=C1C(=O)OCCN(C)CC1C=CC=CC=1)C)C1C=CC=C([N+]([O-])=O)C=1.Cl
CAS Datenbank
54527-84-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 23/24/25
S-S?tze: 36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. US7972100
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Toxizit?t LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado)

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).

Chemische Eigenschaften

Yellow Solid

Verwenden

Dihydropyridine calcium channel blocker. Antianginal; antihypertensive

Allgemeine Beschreibung

Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.

Sicherheitsprofil

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an

2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 386)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd
+8615531151365
mina@chuanghaibio.com China 18126 58
airuikechemical co., ltd.
+86-18353166132
sales02@airuikechemical.com China 983 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368
sales@sjar-tech.com China 529 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58

54527-84-3(2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid)Verwandte Suche:


  • methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • 2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-[Methyl(phenylmethyl)amino]ethyl Ester Hydrochloride
  • Antagonyl
  • Barizin
  • Dacarel
  • Vasonas
  • YC-93
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
  • Vasonase
  • NICARDIPINE HYDROCHLORIDE (YC-93) CALCIU M CHANNEL ANTAG
  • NICARDIPINE HYDROCHLORIDE MM(CRM STANDARD)
  • YC-93, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride
  • Aprovan
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl 5-[2-[Methyl(phenylMethyl)aMino]ethyl] ester, hydrochloride
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester, hydrochloride (1:1)
  • 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-2-(
  • angioglebil
  • benzylmethylamino)ethylmethylester,monohydrochloride
  • bionicard
  • dafil
  • dagan
  • lincil
  • loxen
  • nicardil
  • perdipina
  • rs-69216
  • PERDIPINE
  • NICODEL
  • NICARDIPINE HYDROCHLORIDE
  • YC-93 HCL
  • YC-93 HYDROCHLORIDE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINE-DICARBOXYLIC ACID 3-METHYL ESTER 5-[2-(METHYL-(BENZYL)AMINO)ETHYL] ESTER HYDROCHLORIDE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2- [METHYL-(PHENYLMETHYL)AMINO]ETHYL ESTER HYDROCHLORIDE
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-[3-NITROPHENYL]METHYL-2-[METHYL(PHENYLMETHYL)AMINO]-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
  • Nicardipine Hydrochloride, 99.0+ % (HPLC)
  • NicardipineHydrochloride>
  • Nicardipine for system suitability
  • Nicardipine hydrochloride USP/EP/BP
  • 3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • Antagonil, Dagan, Flusemide)
  • Nicardipine HCl (RS69216
  • Nicardipine 13CD3 Hydrochloride
  • Nicardipine HydrochlorideQ: What is Nicardipine Hydrochloride Q: What is the CAS Number of Nicardipine Hydrochloride Q: What is the storage condition of Nicardipine Hydrochloride Q: What are the applications of Nicardipine Hydrochloride
  • Nicardipine Hydrochloride (1463224)
  • 13C,2H3]-Nicardipine Hydrochloride
  • Nicardipine Hydrochloride, ≥ 98.0%
  • 2-(Benzylmethylamino)ethylmethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylatmonohydrochlorid
  • Nicardipine hydrochloride, L-type Ca2+ channel antagonist
  • Nicardipine hydrochloride, 10 mM in DMSO
  • Nicardipine HCl - Bio-X ?
  • Yulan Magnolia Flower Bud
  • 13C,D3-Nicardipine Hydrochloride
  • 3-(2-(Benzyl(methyl)amino)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylate HCl
  • Naratriptan HCl
  • NICARDIPINE HCL
  • 54527-84-3
  • 5427-84-3
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