4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

388575-52-8

CAS-Nr.: 388575-52-8

Englisch Name:: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

Synonyma:: PSN375963;PSN 375963 hydrochloride;PSN 375963, 10 mM in DMSO;5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole;4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine;Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-;4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride;Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP

CBNumber:: CB12518900

Summenformel:: C17H23N3O

Molgewicht:: 285.38

MOL-Datei:: 388575-52-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 54

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Eigenschaften

Siedepunkt:: 440.1±47.0 °C(Predicted)

Dichte: 1.060±0.06 g/cm3(Predicted)

storage temp.: -20°C

L?slichkeit: DMSO: >10mg/mL

pka: 0.82±0.10(Predicted)

Aggregatzustand: powder

Farbe: white to off-white

InChI: 1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3

InChIKey: OAVLEYPTWABFLF-UHFFFAOYSA-N

SMILES: CCCCC1CCC(CC1)c2nc(no2)-c3ccncc3

Sicherheit

WGK Germany	nwg
Speicherklasse	11 - Combustible Solids

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 54)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15838	69
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4795	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Angel Pharmatech, Ltd.	17317130613	3358272972@qq.com	China	3303	58
BOC Sciences	--	info@bocsci.com	USA	0	65

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride
PSN 375963 hydrochloride
PSN375963
4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine
5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole
Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP
Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-
PSN 375963, 10 mM in DMSO
388575-52-8
C17H23N3OHCl

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