N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine (N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine) is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.

Application

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.

Synthese

2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Yangzhou Qinyuan Pharmatech Co.,ltd	+86-18752526868 +86-18752526868	jennysun@yzqyyykj.com	China	80	58
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

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• N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine
• 2H-Indazol-6-aMine, N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-
• N-(2-chloro-4-pyriMidinyl)-2,3-diMethyl-2H-indazol-6-aMine
• N-(2-chloropyrimidin-4-yl)-2,3-dimethylindazol-6-amine
• 2H-indazol-6aMine,2,3-diMethyl.HCl(1:1)
• 6-[N-(2-chloropyriMidin-4-yl)aMino]-2,3-diMethyl-2H-indazole
• Pazopanib Impurity 20
• BNKY007-PZ01
• N-(2-chloropyriMidin-4-yl)-2,3-diMethyl-2H- indazol-6-aMine ISO 9001：2015 REACH
• N-(2-chloropyrimidin-4-yl)-N,2,3-dimethyl-2H-indazol -6-amine
• N,2,3-trimethyl-N-(2-((4-methyl-3-sulfamoylphenyl)amino)pyrimidin-4-yl)-2H-indazol-6-amine oxidee
• Pazopanil impurity 12
• 444731-74-2
• 44731-74-2