A 419259 trihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

A-419259 is an inhibitor of Src family kinases, including Src, LCK, Lyn, and Hck (IC₅₀s = 9, <3, <3, and 11.26 nM, respectively)., It is selective for these kinases over c-Abl (IC₅₀ = 3,000 nM) and PKC (IC₅₀ = >33 μM). A-419259 inhibits growth of Philadelphia chromosome-positive (Ph⁺) K-562 and Meg-01 myeloid leukemia cells (IC₅₀s = 0.1-0.3 and 0.1 μM, respectively), but not Ph^- TF-1 and HEL cells. It induces apoptosis in K-562 cells in a concentration-dependent manner. A-419259 (300 nM) inhibits differentiation of murine embryonic stem cells while maintaining pluripotency. It reduces the total number of acute myeloid leukemia (AML) cells, as well as AML stem cells, in the bone marrow and spleen in mouse patient-derived xenograft (PDX) models of AML when administered at a dose of 30 mg/kg twice daily.

A 419259 trihydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

A 419259 trihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39037	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19956	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131956	58
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD	13816107857	sales@fortunechem-sh.com	China	981	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2782	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3504	58

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• A 419259
• A419259
• A-419259
• RK 20449
• RK20449
• 7-[Trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
• A 419259 trihydrochloride
• 7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[trans-4-(4-methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-
• A-419259 HCl
• RK-20449
• 364042-47-7