PIK-294
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- CAS-Nr.
- 900185-02-6
- Englisch Name:
- PIK-294
- Synonyma:
- CS-537;PIK-294;PIK-294 ，S2227;PIK294;PIK 294;AR-12 OSU-03012;PIK-294 USP/EP/BP;PIK-294, 10 mM in DMSO;2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)q;2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one;2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
- CBNumber:
- CB12537813
- Summenformel:
- C28H23N7O2
- Molgewicht:
- 489.53
- MOL-Datei:
- 900185-02-6.mol
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PIK-294 Eigenschaften
- Siedepunkt:
- 790.4±70.0 °C(Predicted)
- Dichte
- 1.43
- storage temp.
- -20°C
- L?slichkeit
- ≥24.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- Aggregatzustand
- powder
- pka
- 8.95±0.10(Predicted)
- Farbe
- white to beige
- Wasserl?slichkeit
- H2O: 10mg/mL, clear
DMSO: 5mg/mL, clear (warmed)
- InChIKey
- WFSLJOPRIJSOJR-UHFFFAOYSA-N
- SMILES
- NC1=C2C(N(CC(N3C4=C(C)C=CC=C4)=NC5=C(C(C)=CC=C5)C3=O)N=C2C6=CC(O)=CC=C6)=NC=N1
- CAS Datenbank
- 900185-02-6
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
WGK 3 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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PIK-294 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
PIK-294 is a derivative of PIK-293 (P437700) and a highly selective inhibitor of p110δ which is an isoform of phosphoinositide 3-kinase (PI3K).
Biochem/physiol Actions
PIK-294 is a highly selective inihibitor of the phosphoinositide 3-kinase (PI3K) p110δ with an IC50 value of 10 nM compared to IC50 values of 10 μM, 490 nM and 160 nM for PI3Kα/β/γ, respectively. PIK-294 has been used to help distinguish the unique roles of the various PI3-K isoforms. For example, in a study of CXCL8-induced neutrophil migration, PIK-294 inhibited both chemokinetic and chemotactic CXCL8-induced migration whereas PI3Kγ inhibitor AS-605240 markedly reduced CXCL8 induced chemokinetic migration but had no effect on CXCL8 induced chemotactic migration.
PIK-294 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PIK-294 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 127)Lieferanten
900185-02-6()Verwandte Suche:
- 4(3H)-Quinazolinone, 2-[[4-aMino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]Methyl]-5-Methyl-3-(2-Methylphenyl)-
- 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
- 2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)q
- PIK-294
- 2-[[4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
- PIK294;PIK 294
- CS-537
- PIK-294 USP/EP/BP
- AR-12 OSU-03012
- PIK-294, 10 mM in DMSO
- PIK-294 ，S2227
- 900185-02-6
- Inhibitors
- Akt
- mTOR
- PI3K
