LY2090314
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- CAS-Nr.
- 603288-22-8
- Englisch Name:
- LY2090314
- Synonyma:
- 3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione;CS-843;LY2090314;LY2090314 100MG;LY2090314 ，S7063;LY2090314 USP/EP/BP;LY 2090314;LY-2090314;LY2090314 >=98% (HPLC);LY2090314;LY 2090314;LY-2090314;3-[9-Fluoro-1,2,3,4-Tetrahydro-2-(1-Piperidinylcarbonyl)Pyrrolo[3,2,1-Jk][1,4]Benzodiazepin-7-Yl]-4-Imidazo[1,2-A]Pyridin-3-Yl-1H-Pyrrole-2,5-Dione
- CBNumber:
- CB12628063
- Summenformel:
- C28H25FN6O3
- Molgewicht:
- 512.53
- MOL-Datei:
- 603288-22-8.mol
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LY2090314 Eigenschaften
- Dichte
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- insoluble in H2O; ≥91 mg/mL in DMSO; ≥4.27 mg/mL in EtOH with gentle warming and ultrasonic
- pka
- 7.41±0.60(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow to orange
- InChIKey
- HRJWTAWVFDCTGO-UHFFFAOYSA-N
- SMILES
- O=C(N1CCCCC1)N(C2)CCN3C4=C2C=C(F)C=C4C(C5=C(C6=CN=C7N6C=CC=C7)C(NC5=O)=O)=C3
- CAS Datenbank
- 603288-22-8
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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LY2090314 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
LY 2090314 is a novel glycogen synthase kinase-3α inhibitor for the treatment of acute myeloid leukemia.
Biochem/physiol Actions
LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) currently in clinical trials for cancer therapy. LY2090314 has IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.
LY2090314 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LY2090314 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 128)Lieferanten
- LY2090314
- 7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine
- 7-(2,5-Dihydro-4-imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepine LY2090314
- LY2090314;LY 2090314;LY-2090314
- LY2090314 100MG
- CS-843
- LY 2090314;LY-2090314
- 1H-Pyrrole-2,5-dione, 3-[9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinylcarbonyl)pyrrolo[3,2,1-jk][1,4]benzodiazepin-7-yl]-4-imidazo[1,2-a]pyridin-3-yl-
- LY2090314 >=98% (HPLC)
- LY2090314 USP/EP/BP
- LY2090314 ，S7063
- 3-[9-Fluoro-1,2,3,4-Tetrahydro-2-(1-Piperidinylcarbonyl)Pyrrolo[3,2,1-Jk][1,4]Benzodiazepin-7-Yl]-4-Imidazo[1,2-A]Pyridin-3-Yl-1H-Pyrrole-2,5-Dione
- 3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione
- 603288-22-8
- C28H25FN6O3
- Inhibitors
- Akt
- mTOR
- PI3K
