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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Struktur
915095-86-2
CAS-Nr.
915095-86-2
Englisch Name:
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Synonyma:
Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;(2-Chloro-5-sulfophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
CBNumber:
CB12651407
Summenformel:
C13H7ClFIO
Molgewicht:
360.55
MOL-Datei:
915095-86-2.mol

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Eigenschaften

Schmelzpunkt:
64-70℃
Siedepunkt:
415℃
Dichte
1.752
Flammpunkt:
205℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
L?slichkeit
Chloroform (Slightly), Ethyl Acetate
Aggregatzustand
Solid
Farbe
Off-White
InChI
InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
InChIKey
KNYGUQLVFSPVRI-UHFFFAOYSA-N
SMILES
C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 24/25
HS Code  29142990
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.

Synthese

5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 257)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-86-2386815286 +8613983794297
sales@ensky-chemical.com China 94 58
Suzhou Nordica Biopharma CO.,LTD
+86-18136148818 +86-18567353071
3537297702@qq.com China 299 58
Cangzhou Kangrui Pharma Tech Co. Ltd.,
+86-18632776803 +86-13833998158
cangzhoukangrui@126.com China 773 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29640 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Shandonghaohong biotechnology Co.,ltd.
0635-6175299 13961496334
sale@inyelchem.com CHINA 44 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10403 58

915095-86-2()Verwandte Suche:


  • (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
  • Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
  • (2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone
  • Empagliflozin Impurity 48
  • Englenet Impurity 16
  • 2-chloro-4-fluoro-5-Iodobenzophenon
  • (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon
  • 2-Chloro-4'-fluoro-5-iodobenzophenone
  • (2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone
  • Empagliflozin Impurity 48 /Englenet Impurity 16
  • (2-Chloro-5-sulfophenyl)(4-fluorophenyl)methanone
  • 915095-86-2
  • 945065-86-2
  • C13H7ClFIO
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