Teneligliptin Hydrobromide
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- CAS-Nr.
- 906093-29-6
- Englisch Name:
- Teneligliptin Hydrobromide
- Synonyma:
- Teneligliptin HydrobroMide Hydrate;Teneligliptin HBr;3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O;MP-513;API(Teneligliptin hydro bromide hydrate);3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5);[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide;teneligliptin（INN）;MP-513 (hydrobromide);Ticagrelor hydrobromide
- CBNumber:
- CB12666692
- Summenformel:
- C22H31BrN6OS
- Molgewicht:
- 507.5
- MOL-Datei:
- 906093-29-6.mol
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Teneligliptin Hydrobromide Eigenschaften
- Schmelzpunkt:
- >211°C (dec.)
- storage temp.
- Refrigerator
- L?slichkeit
- Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Light Beige
- Optische Rotation
- [α]/D -28 to -36°, c =0.5 in methanol
- Wasserl?slichkeit
- H2O: 2mg/mL, clear
- InChIKey
- ZBCRQDMAUHALHD-MCMUQQEGNA-N
- SMILES
- CC1=NN(C2C=CC=CC=2)C(N2CCN([C@@H]3CN[C@H](C(N4CSCC4)=O)C3)CC2)=C1.Br |&1:15,18,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Teneligliptin Hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
Clinical Use
Teneligliptin Hydrobromide is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name Tenelia?. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1 levels, with very low rates of renal excretion.
Synthese
The only reported synthesis of teneligliptin is described in the scheme below. Reaction of commercially
available N-Boc-piperazine (158) with diketene (159) in DMF at room temperature gave acetoacetamide
160 in 86% yield, and this material was immediately condensed with phenylhydrazine in
methanesulfonic acid followed by a cyclodehydration with phosphorus oxychloride to give pyrazole 161
in 12% yield. The t-butyl carbamate was then removed with TFA in dichloromethane to give amine 162
in 88% yield. This amine was then subjected to butyrolactam 165 (which was prepared from N-Boctrans-
4-hydroxy-L-proline (163) coupled with thiazolidine (164) under conventional amide-forming
conditions using EDC) in the presence of sodium triacetoxy borohydride (STAB-H) in acetic acid.
This reductive amination reaction afforded the cis-aminopyrrolidine 166 exclusively in 50% yield.
Removal of the t-butyl carbamate group with TFA afforded the teneligliptin free amine in 93% yield,
and this freebase was then subsequently treated with 48% hydrobromic acid in refluxing ethanol to give
teleligliptin hydrobromide hydrate (XXV) in 90% yield.
Teneligliptin Hydrobromide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Teneligliptin Hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 235)Lieferanten
- Teneligliptin (hydrobroMide)
- Teneligliptin HydrobroMide (2:5)
- MP-513 (hydrobromide)
- Teneligliptin hydrobromide anhydrous
- TENELIGLIPTIN HEMIPENTA HYDROBROMIDE HYDRATE
- ((2S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone
- 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piper...
- Teneligliptin hydrobromideQ: What is
Teneligliptin hydrobromide Q: What is the CAS Number of
Teneligliptin hydrobromide Q: What is the storage condition of
Teneligliptin hydrobromide Q: What are the applications of
Teneligliptin hydrobromide
- Teneligliptin Hydrobromide API
- 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5)
- [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide
- API(Teneligliptin hydro bromide hydrate)
- 3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O
- Teneligliptin(hydrobromide)-amorphous
- Bis(((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone) pentahydrobromide
- Methanone, [(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-, hydrobromide (2:5)
- (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-Methanone hydrobromide (2:5)
- Ticagrelor hydrobromide
- Teneligliptin HBr
[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]- 2-pyrrolidinyl]-3-thiazolidinylmethanone HBr
- Tepagliptin (Hydrobromide)
- (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl]-3-thiazolidinyl-methanone HBr (2:5)
- Teneligliptin Hydrobromide Hydrate（JAN）
- teneligliptin（INN）
- Teglitazide Hydrobromide
- MP-513
- Teneligliptin HydrobroMide Hydrate
- Teneligliptin HBr
- 906093-29-6
- 906093-37-1
- 2C22H30N6OS5HBr
- C44H65Br5N12O2S2
- 2C22H30N6OS5BrH
- API
