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Oxaprozin

Oxaprozin Struktur
21256-18-8
CAS-Nr.
21256-18-8
Bezeichnung:
Oxaprozin
Englisch Name:
Oxaprozin
Synonyma:
3-(4,5-Diphenyloxazol-2-yl)propanoic acid;CB1272505;OXAPROZINE;DAYPRO;3-(diphenyl-1,3-oxazol-2-yl)propanoic acid;Alvo;Oxapro;Durapro;Actirin;wy-21743
CBNumber:
CB1272505
Summenformel:
C18H15NO3
Molgewicht:
293.32
MOL-Datei:
21256-18-8.mol

Oxaprozin Eigenschaften

Schmelzpunkt:
154 °C
Siedepunkt:
435.17°C (rough estimate)
Dichte
1.2278 (rough estimate)
Brechungsindex
1.5100 (estimate)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
solid
pka
4.3(at 25℃)
Farbe
Crystals from methanol
Wasserl?slichkeit
4mg/L(37 ºC)
Merck 
14,6924
BCS Class
2
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Major Application
pharmaceutical (small molecule)
InChI
1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChIKey
OFPXSFXSNFPTHF-UHFFFAOYSA-N
SMILES
OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3
CAS Datenbank
21256-18-8(CAS DataBase Reference)
EPA chemische Informationen
2-Oxazolepropanoic acid, 4,5-diphenyl- (21256-18-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 20/21/22-36/37/38
S-S?tze: 24/25-36/37/39-36-26
WGK Germany  3
RTECS-Nr. RP6990000
Hazard Note  Irritant
HS Code  29349990
Speicherklasse 11 - Combustible Solids
Giftige Stoffe Daten 21256-18-8(Hazardous Substances Data)
Toxizit?t TDLo orl-rbt: 39 mg/kg (female 6-18D post):TER IYKEDH 15,250,84
Bildanzeige (GHS) Corrosion (GHS05)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Oxaprozin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long T1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3- substituted, rather than a 2-substituted propionic acid.

Chemische Eigenschaften

White Solid

Verwenden

Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).

Definition

ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit s and rheumatoid arthritis.

Indications

Oxaprozin (Daypro) is approved for the treatment of osteoarthritis and rheumatoid arthritis. Its long halflife allows for once daily dosing.The most frequently reported adverse effects of this drug are nausea, vomiting, and dyspepsia.

Allgemeine Beschreibung

Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.

Pharmakokinetik

Oxaprozin is well absorbed (100%) following oral administration, but maximum plasma concentrations are not reached until 3 to 5 hours following ingestion. Oxaprozin is an anti-inflammatory agent possessing a rapid onset of action and a prolonged duration of action. In both the carrageenan raw paw edema assay and analgetic tests, it was equipotent with aspirin. Oxaprozin has been associated with the appearance of rash and/or mild photosensitivity. Some patients experience an increased incidence of rash on sun-exposed skin during clinical testing.

Sicherheitsprofil

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.

Oxaprozin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Oxaprozin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 330)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
Fuxin Pharmaceutical
+86-021-021-50872116 +8613122107989
contact@fuxinpharm.com China 10000 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051
joe@yuhengpharm.com CHINA 21142 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 8741 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58

21256-18-8(Oxaprozin)Verwandte Suche:


  • Dxaprozin
  • OXAPROZIN (3-(4,5-DIPHENYL-2-OXAZOLYL)PROPIONIC ACID)
  • 4,5-Diphenyl-2-oxazolepropanoic acid, Daypro
  • 2-Oxazolepropanoic acid, 4,5-diphenyl-
  • Durapro
  • Oxapro
  • Oxaprozin (200 mg)
  • 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic acid 97%
  • 3-(4,5-Diphenyloxazol-2-yl)propionic Acid
  • Actirin
  • Duraprost
  • NSC 310839
  • β-(4,5-Diphenyloxazol-2-yl)propionic Acid
  • 4,5-DIPHENYL-2-OXAZOLEPROPANOIC ACID
  • 3-(4,5-DIPHENYL-1,3-OXAZOL-2-YL)PROPANOIC ACID
  • 3-(4,5-DIPHENYL-1,3-OXAZOL-2-YL)PROPIONIC ACID
  • 3-(4,5-DIPHENYL-2-OXAZOLYL)PROPIONIC ACID
  • OXAPROSIN
  • OXAPROZIN
  • 4,5-Diphenyloxazole-2-propionic acid
  • Alvo
  • 4,5-Diphenyl-2-oxazolepropanoicacid\Oxaprozin
  • Oxaprozin,4,5-Diphenyl-2-oxazolepropanoic acid, Daypro
  • Oxaprozin, 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propionic acid, 2-(2-Carboxyethyl)-4,5-diphenyl-1,3-oxazole
  • Oxaprozin, Actirin
  • Oxaprozin Solution, 100ppm
  • 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoicacid97%
  • 4,5-diphenyl-2-oxazolepropanoicaci
  • 4,5-diphenyl-2-oxazolepropionicaci
  • 4,5-diphenyl-2-oxazolepropionicacid
  • wy-21743
  • 3-(4,5-Diphenyl-2-oxazoyl)propionic acid
  • Oxaprozinum
  • Oxaprozin, 98%, a pancreatic and gastric lipase inhibitor and caspase-3 activator
  • 3-(4,5-diphenyl-2-oxazolyl)propanoic acid
  • Oxaprozin>
  • Oxaprozin Oxaprozin
  • Oxaprozin USP/EP/BP
  • Oxaprozin (Oxaprozinum
  • OxaprozinQ: What is Oxaprozin Q: What is the CAS Number of Oxaprozin Q: What is the storage condition of Oxaprozin
  • Oxaprozin (1482207)
  • DAYPRO
  • 3-(diphenyl-1,3-oxazol-2-yl)propanoic acid
  • Oshapqin
  • Oxaprozin, 10 mM in DMSO
  • Oxaprozin - Bio-X ?
  • Oxaprozin (Standard)
  • 3-(4,5-Diphenyloxazol-2-yl)propanoic acid
  • CB1272505
  • OXAPROZINE
  • 21256-18-8
  • C18H15NO3
  • Immune System Regulation
  • Immunomodulators and Antibiotics
  • Immune Cell Signaling and Blood
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
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