"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
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- CAS-Nr.
- 14892-97-8
- Englisch Name:
- "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- Synonyma:
- -2-suL;SCR7 ，S7742;6,7-diphenyL;SCR7 pyrazine;SCR7; SCR-7; SCR 7.;6,7-Diphenyl-2-thiolumazine;SCR7 pyrazine, 10 mM in DMSO;SCR7 pyrazine, NHEJ inhibitor;6,7-Diphenyl-2-sulfanylpteridin-4-ol;"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- CBNumber:
- CB12741690
- Summenformel:
- C18H12N4OS
- Molgewicht:
- 332.38
- MOL-Datei:
- 14892-97-8.mol
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"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Eigenschaften
- Schmelzpunkt:
- 209 °C
- Dichte
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.14±0.60(Predicted)
- Aggregatzustand
- powder
- Farbe
- faintly yellow to dark yellow
- InChI
- 1S/C18H12N4OS/c23-17-15-16(21-18(24)22-17)20-14(12-9-5-2-6-10-12)13(19-15)11-7-3-1-4-8-11/h1-10H,(H2,20,21,22,23,24)
- InChIKey
- GSRTWXVBHGOUBU-UHFFFAOYSA-N
- SMILES
- O=C(C1=C(N2)N=C(C3=CC=CC=C3)C(C4=CC=CC=C4)=N1)NC2=S
- CAS Datenbank
- 14892-97-8
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
2933.59.8000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
SCR7 pyrazine has been used as a non-homologous end joining (NHEJ) modulator to study its effect on CRISPR/Cas9-mediated editing.
Allgemeine Beschreibung
SCR7 pyrazine is an inhibitor of DNA ligase IV.
Biochem/physiol Actions
SCR7 pyrazine is reported to be an inhibitor of non-homologous end joining (NHEJ) and has been shown to enhance the efficiency of CRISPR-Cas9 genome editing. The effect of SCR7 pyrazine on the efficiency and targeting precision of CRISPR applications has been shown to be cell type specific and context dependent. SCR7 pyrazine is a product of spontaneous cyclization of SCR7, first reported by Srivastava, M., et al.
"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 105)Lieferanten
- "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
- 6,7-Diphenyl-2-thiolumazine
- SCR7 pyrazine
- 6,7-Diphenyl-2-sulfanylpteridin-4-ol
- 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
- SCR7; SCR-7; SCR 7.
- 6,7-diphenyL
- 4(1H)-Pteridinone, 2,3-dihydro-6,7-diphenyl-2-thioxo-
- -2-suL
- 6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(8H)-one
- 6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(1H)-one
- phosphorylation,nonhomologous,Caspase 9,Inhibitor,gene,DNA/RNA Synthesis,end-joining,Apoptosis,DNA,SCR7 pyrazine,replacement,SCR-7 pyrazine,CRISPR/Cas9,ligase-IV,Caspase 3,inhibit,anticancer
- SCR7 pyrazine, NHEJ inhibitor
- SCR7 pyrazine, 10 mM in DMSO
- SCR7 ，S7742
- 14892-97-8
