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10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid

Trifluoperazine dihydrochloride Struktur
440-17-5
CAS-Nr.
440-17-5
Bezeichnung:
10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid
Englisch Name:
Trifluoperazine dihydrochloride
Synonyma:
TRIFLUOPERAZINE HCL;TRIFLUOPERAZINE HYDROCHLORIDE;Trifluoperazine dihydrochloride, 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride;Urinox;skf5019;Stelazin;eskazine;STELAZINE;Eskazinyl;Ai3-50137
CBNumber:
CB1274387
Summenformel:
C21H26Cl2F3N3S
Molgewicht:
480.42
MOL-Datei:
440-17-5.mol

10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid Eigenschaften

Schmelzpunkt:
243 °C (dec.)(lit.)
Flammpunkt:
9℃
storage temp. 
-20°C
L?slichkeit
ethanol: soluble5mg/mL
pka
pK1 3.9, pK2 8.1(at 25℃)
Aggregatzustand
powder
Farbe
white to off-white
Wasserl?slichkeit
water: 50g/L, clear
maximale Wellenl?nge (λmax)
312nm(MeOH)(lit.)
Merck 
14,9680
BRN 
3820024
Stabilit?t:
Hygroscopic
InChI
1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
InChIKey
BXDAOUXDMHXPDI-UHFFFAOYSA-N
SMILES
Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
CAS Datenbank
440-17-5(CAS DataBase Reference)
EPA chemische Informationen
10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 36
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS-Nr. SP1750000
3-10
TSCA  TSCA listed
HazardClass  9
HS Code  29343000
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Muta. 2
STOT RE 1
STOT SE 3
Bildanzeige (GHS) Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenit?t Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
H372 Sch?digt bei Hautkontakt und Verschlucken die Organe bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 1 Achtung P260, P264, P270, P314, P501
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P273 Freisetzung in die Umwelt vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Trifluoperazine (TFP) is a phenothiazine compound with anti-adrenergic and anti-dopaminergic actions typical of antipsychotic agents. It antagonizes adrenergic receptors, with selectivity for α1 over the α2 subtypes (Kis = 24, 653, 163, and 391 nM for α1A, α2A, α2B, and α2C, respectively). TFP binds with much higher affinity to the dopamine D2-like receptor (Kd = 0.96 nM) compared to the dopamine D4-like and the serotonin 5-HT2A receptors (Kds = 44 and 135 nM, respectively). Furthermore, TFP antagonizes calmodulin (CaM) and alters the calcium-binding properties of calsequestrin (CSQ). TFP has been shown to activate type-2 ryanodine receptors independently of its CaM and CSQ activity.

Chemische Eigenschaften

Cream Fine Powder

Verwenden

Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.

Allgemeine Beschreibung

Trifluoperazinehydrochloride, 10-[3-(4-Methyl-1-piperazinyl)propyl-[2-(trifluoromethyl)phenothiazine dihydrochloride (Stelazine).The absorption of trifluoperazine is erratic and variable andit is widely distributed into tissues. The excretion of trifluoperazineoccurs 50% via kidneys and the other 50% isthrough enterohepatic circulation. The metabolism and druginteractions of trifluoperazine are the same as with the otherphenothiazines. Trifluoperazine does not show any specificdrug interactions. Trifluoperazine is indicated for the managementof schizophrenia and short-term treatment ofnonpsychotic anxiety.

Sicherheitsprofil

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F-, NOx, SOx, and HCl. See also FLUORIDES.

l?uterung methode

Recrystallise the salt from absolute EtOH, filter the crystals, dry them in vacuo and store them in tightly stoppered bottles because it is hygroscopic. It is soluble in H2O but insoluble in *C6H6, Et2O and alkaline aqueous solution. It has UV at 258 and 307.5nm (log 4.50 and 3.50) in EtOH (neutral species). [Craig max et al. J Org Chem 22 709 1957.] It is a calmodulin inhibitor [Levene & Weiss J Parmacol Exptl Ther 208 454 1978] and is a psychotropic agent [Fowler Arzneim.-Forsch 27 866 1977]. [Beilstein 27 III/IV 1353.]

10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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440-17-5(10-(3-(4-Methyl-1-piperazinyl)-propyl)-2-(trifluor-methyl)-10H-dihydrochlorid)Verwandte Suche:


  • LABOTEST-BB LT00452002
  • 10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]-2-TRIFLUOROMETHYL-PHENOTHIAZINE DIHYDROCHLORIDE
  • 10-[3-(4-METHYLPIPERAZIN-1-YL)PROPYL]-2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZINE DIHYDROCHLORIDE
  • TRIFLUOPERAZINE 2HCL
  • TRIFLUOPERAZINE DIHYDROCHLORIDE
  • STELAZINE
  • STELAZINE DIHYDROCHLORIDE
  • 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-phenothiazindihy
  • 10-(3-(4-methyl-1-piperazinyl)propyl)-2-trifluoromethylphenothiazinedihydroc
  • tryptazine
  • trifluoperazine hydrochloride usp
  • 10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride
  • Eskazinyl
  • Stelazin
  • Trifluoperazine hydrochloride (JAN/USP)
  • TRIFLUOROPERAZINEHCL
  • TRIFLUOPERZINE HCL
  • 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl) propyl]-2-(trifluoromethyl)-, dihydrochloride
  • TRIFLUONERAZINEHYDROCHLORIDE
  • 10-[3-(4-methylpiperazin-1-yl)-propyl]-2-trifluormethylphenothiazine, dihydrochloride
  • TRIFLUOPERAZINE 2H
  • 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, hydrochloride (1:2)
  • 2-Trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine dihydrochloride
  • Ai3-50137
  • Calmazine
  • Einecs 207-123-0
  • Trifluoperazine Hydrochloride (200 mg)
  • Trifluoperazine DiHCl
  • 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10h-phenothiazin
  • eskazine
  • skf5019
  • trifluoroperazinedihydrochloride
  • trifluoroperazinehydrochloride
  • trifluoropyrazindihydrochloride
  • trifluperazinedihydrochloride
  • triphthazinedihydrochloride
  • Trifluoperazine dihydrochloride solution
  • 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine hydrochloride
  • Three hydrochloric acid
  • Trifluoperazine dihydrochloride, 99%, a cell-permeable calmodulin antagonist
  • Trifluoperazine dihydochloride
  • Trifluoperazine hydrochloride CRS
  • Urinox
  • uoperazine DihydrochL
  • Trifluoperazine dihydrochloride USP/EP/BP
  • Trifluoperzine Hydrochloride
  • TRIFLUOPERAZINE 2HCL (TFP
  • Trifluoperazine DihydrochlorideQ: What is Trifluoperazine Dihydrochloride Q: What is the CAS Number of Trifluoperazine Dihydrochloride Q: What is the storage condition of Trifluoperazine Dihydrochloride Q: What are the applications of Trifluoperazine Dihydrochloride
  • Trifluoperazine hydrochlorideQ: What is Trifluoperazine hydrochloride Q: What is the CAS Number of Trifluoperazine hydrochloride
  • Trifluoperazine Hydrochloride (1685000)
  • Triflurazine hydrochloride
  • TRIFLUOPERAZINE HCL IP/BP/USP
  • Trifluoperazine dihydrochloride in methanol
  • Trifluoperazine dihydrochloride, calmodulin antagonist
  • Tryptazine dihydrochloride
  • Trifluoperazine Dihydrochloride USP
  • Trifluoperazine Hydrochloride 1.0 mg/ml in Methanol (as free base)
  • Trifluoperazine.2HCl, 1mg/ml in Methanol (as free base)
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