[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
CAS-Nr.
1360705-96-9
Englisch Name:
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
Synonyma:
ML 210;CID 49766530;ML 210 >=98% (HPLC);ML-210, 10 mM in DMSO;ML 210 - CID 49766530;(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone;[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone;Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-;[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone;residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,ML 210,ML210,glutathione,Inhibitor,GPX4,anti-cancer
CBNumber:
CB12750494
Summenformel:
C22H20Cl2N4O4
Molgewicht:
475.32
MOL-Datei:
1360705-96-9.mol
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Eigenschaften
Siedepunkt:
644.7±55.0 °C(Predicted)
Dichte
1.415±0.06 g/cm3(Predicted)
storage temp.
2-8°C
L?slichkeit
Soluble in DMSO (up to 30 mg/ml)
pka
4.69±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI
1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3
InChIKey
VIBHJPDPEVVDTB-UHFFFAOYSA-N
SMILES
Cc1onc(C(=O)N2CCN(CC2)C(c3ccc(Cl)cc3)c4ccc(Cl)cc4)c1[N+]([O-])=O
Sicherheit
Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)
WGK Germany
3
Speicherklasse
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
Bildanzeige (GHS)
Alarmwort
Warnung
Gefahrenhinweise
Code
Gefahrenhinweise
Gefahrenklasse
Abteilung
Alarmwort
Symbol
P-Code
H302
Gesundheitssch?dlich bei Verschlucken.
Akute Toxizit?t oral
Kategorie 4
Warnung
P264, P270, P301+P312, P330, P501
Sicherheit
P280
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
ML 210 has been used as a glutathione peroxidase 4 (GPX4) inhibitor to induce ferroptosis in cancer cells. It has also been used as a GPX4 inhibitor to examine whether pharmacological inhibition of GPX4 altered prominin2 expression and impacted ferroptosis in adherent MCF10A and Hs578t cells.
Biochem/physiol Actions
ML 210 induces non-apoptotic cell death in tumor cells expressing the RAS oncogene.
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 78)Lieferanten
China 67
United Kingdom 1
United States 10
Global 78
1360705-96-9()Verwandte Suche:
[4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
CID 49766530
ML 210
[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
ML 210 - CID 49766530
Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-
ML 210 >=98% (HPLC)
(4-(Bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,ML 210,ML210,glutathione,Inhibitor,GPX4,anti-cancer
ML-210, 10 mM in DMSO
1360705-96-9