Raloxifene
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- CAS-Nr.
- 84449-90-1
- Englisch Name:
- Raloxifene
- Synonyma:
- RALOXIFEN;Evista;(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone;RALOXAFINE;RALOXIFENE;RALOXIFENE-D7;Raloxifene CRS;LY156758 free base;Raloxifene USP/EP/BP;Raloxifene hydrochlo
- CBNumber:
- CB1290431
- Summenformel:
- C28H27NO4S
- Molgewicht:
- 473.58
- MOL-Datei:
- 84449-90-1.mol
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Raloxifene Eigenschaften
- Schmelzpunkt:
- 250-253°C
- Siedepunkt:
- 728.2±60.0 °C(Predicted)
- Dichte
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- L?slichkeit
- DMSO: 28 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- 8.83±0.15(Predicted)
- Farbe
- light yellow
- Wasserl?slichkeit
- 560μg/L at 25℃
- InChI
- InChI=1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2
- InChIKey
- GZUITABIAKMVPG-UHFFFAOYSA-N
- SMILES
- C(C1=C(C2=CC=C(O)C=C2)SC2=CC(O)=CC=C21)(C1=CC=C(OCCN2CCCCC2)C=C1)=O
- LogP
- 6.09
- CAS Datenbank
- 84449-90-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H311 |
Giftig bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 3 |
Achtung |
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P280, P302+P352, P312, P322, P361,P363, P405, P501 |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
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| H411 |
Giftig für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 2 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P322 |
Gezielte Ma?nahmen |
| P361 |
Alle kontaminierten Kleidungsstücke sofort ausziehen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Raloxifene Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light-Yellow Solid
Verwenden
Raloxifene is a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
Indications
Raloxifene (Evista) is a new SERM approved for
use in the treatment and prevention of osteoporosis because
it has estrogenic activity in bone. Raloxifene is an
estrogen antagonist in both breast and endometrial tissues.
The estrogenlike properties of raloxifene result in
the maintenance of a favorable serum lipid profile (decreased
low-density lipoprotein levels with no change
in either high-density lipoproteins or triglycerides).
Raloxifene is 95% bound to plasma proteins. Absorption
of raloxifene is impaired by cholestyramine.
Definition
ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Allgemeine Beschreibung
Raloxifene, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone (Evista), is a benzothiophene derivativethat differs slightly from the triphenylethyleneSERMs. A key structural difference is the carbonyl “hinge”that connects the modified phenolic side chain to the benzothiophenering system. This hinge is the key structural elementthat leads to the differing actions at the ERs.Raloxifene, unlike tamoxifen and toremifene, has antagonistproperties on the endometrium and breast tissue and agonistproperties on bone and the cardiovascular system. The lackof agonist action on endometrial tissue has been suggestedas a reason for the lack of endometrial cancer associatedwith raloxifene use. Raloxifene is approved for the preventionand treatment of osteoporosis in postmenopausalwomen. It has also been investigated for preventing breastcancer in comparison with tamoxifen. Recent studies indicatesthat it has similar effectiveness to tamoxifen, but has apreferable side effect profile.
Biologische Aktivit?t
Selective estrogen receptor modulator (SERM) that binds to ER α and ER β , and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC 50 of 1 nM.
Clinical Use
Raloxifene, the first SERM
approved for the prevention of osteoporosis in postmenopausal women, acts as an estrogen agonist on
receptors in osteoblasts and osteoclasts but as an antagonist at breast and uterine estrogen receptors.
Raloxifene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Raloxifene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 170)Lieferanten
84449-90-1()Verwandte Suche:
- [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone
- [4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL
- RALOXAFINE
- [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
- [6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride
- Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
- [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] ketone
- [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
- 2-(4-Hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene-6-ol
- [6-Hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone
- (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methan
- RALOXIFENE
- Raloxifene CRS
- Raloxifene for peak identification CRS
- Raloxifene USP/EP/BP
- 99% Purity Raloxifene
- Raloxifene hydrochlo
- RALOXIFENE-D7
- Raloxifene (Evista, RAL) (65)-1 gram
- Evista
- LY156758 free base
- (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone
- RALOXIFEN
- 84449-90-1
- C28H28ClNO4S
- C28H27NO4S
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Estrogen
- Cytokines, Growth Factors and Hormones
- Hormones
- Steroid Hormones
- Raloxifene
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Pharmaceutical intermediate
