DELAVIRDINE, MESYLATE
|
|
|
- CAS-Nr.
- 147221-93-0
- Englisch Name:
- DELAVIRDINE, MESYLATE
- Synonyma:
- C08087;U-90152S;U 90152 (mesylate);elavirdinemesylate;Seebio Delavirdine;Delavirdine Mesylat;Delavirdine mesilate;BHAP-U 90152 (mesylate);Delavirdine methane sulfonate;DELAVIRDINE (MESYLATE);U 90152
- CBNumber:
- CB1292152
- Summenformel:
- C23H32N6O6S2
- Molgewicht:
- 552.67
- MOL-Datei:
- 147221-93-0.mol
|
DELAVIRDINE, MESYLATE Eigenschaften
- Schmelzpunkt:
- 118-120°C
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- DMSO: >5mg/mL
- Aggregatzustand
- powder
- Farbe
- white to tan
- InChIKey
- MEPNHSOMXMALDZ-UHFFFAOYSA-N
- SMILES
- CS(O)(=O)=O.CC(C)Nc1cccnc1N2CCN(CC2)C(=O)c3cc4cc(NS(C)(=O)=O)ccc4[nH]3
- CAS Datenbank
- 147221-93-0
DELAVIRDINE, MESYLATE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Rescriptor was launched in the US for HIV positive individuals. It can be
prepared in seven steps from 2-chloro-3-nitropyridine and piperazine. Rescriptor is a member of the bis(heteroaryl)piperazine (BHAP) class of non-nucleoside HIV-1
reverse transcriptase inhibitors (NNRTIs) of which it is a second generation drug. It
acts exclusively as an allosteric mixed inhibitor of both RNA- and DNA-directed
polymerase domains of RT and has a much higher binding affintiy for the enzymesubstrate
complex than for the free enzyme. Rescriptor does not inhibit RNase H
activity of RT. It prevented the spread of HIV significantly longer than AZT.
Development of resistance to Rescriptor can occur, however the mutated strain
becomes more vulnerable to other members of the NNRTIs. It is metabolized in the
liver by CYP3A.
Chemische Eigenschaften
Light Brown Solid
Definition
ChEBI: The monomethanesulfonic acid salt of delavirdine, a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt)
with other antiretrovirals for combination therapy of HIV infection.
DELAVIRDINE, MESYLATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DELAVIRDINE, MESYLATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 118)Lieferanten
- C08087
- Delavirdine mesilate
- MethanesulfonaMide, N-[2-[[4-[3-[(1-Methylethyl)aMino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, Methanesulfonate
- N-[2-[[4-[3-[(1-Methylethyl)aMino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]MethanesulfonaMide Methanesulfonate
- Delavirdine methane sulfonate
- N-[2-[[4-[3-[(1-Methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]methanesulfonamide mesylate
- U-90152S
- DELAVIRDINE (MESYLATE);U 90152
- 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
- DELAVIRDINE MESYLATE (U 90152 MESYLATE)
- BHAP-U 90152 (mesylate)
- U 90152 (mesylate)
- Delavirdine Mesylat
- N-(2-(4-(3-(Isopropylamino)pyridin-2-yl)piperazine-1-carbonyl)-1H-indol-5-yl)methanesulfonamide methanesulfonate
- elavirdinemesylate
- Delavirdine mesylate, 10 mM in DMSO
- Seebio Delavirdine
- 147221-93-0
- C22H28N6O3SCH4SO3
- C22H28N6O3SCH4O3S
- C23H32N6O6S2
- Anti-viral Compounds
- Anti-virals
- Inhibitors
- Intermediates & Fine Chemicals
- Non-nucleoside Reverse Transcriptase
- Pharmaceuticals
