VR23
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- CAS-Nr.
- 1624602-30-7
- Englisch Name:
- VR23
- Synonyma:
- VR23;CS-1579;VR23(VR-23);VR23 ，S7933;VR23[SML1599];VR23 >=98% (HPLC);VR23, 10 mM in DMSO;7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline;7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline;Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-
- CBNumber:
- CB13049249
- Summenformel:
- C19H16ClN5O6S
- Molgewicht:
- 477.88
- MOL-Datei:
- 1624602-30-7.mol
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VR23 Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- insoluble in EtOH; insoluble in H2O; ≥45.55 mg/mL in DMSO
- Aggregatzustand
- Powder
- Farbe
- Light yellow to yellow
- InChI
- 1S/C19H16ClN5O6S/c20-13-1-3-15-16(11-13)21-6-5-17(15)22-7-9-23(10-8-22)32(30,31)19-4-2-14(24(26)27)12-18(19)25(28)29/h1-6,11-12H,7-10H2
- InChIKey
- PDQVZPPIHADUOO-UHFFFAOYSA-N
- SMILES
- [S](=O)(=O)(N2CCN(CC2)c3c4c(ncc3)cc(cc4)Cl)c1c(cc(cc1)[N+](=O)[O-])[N+](=O)[O-]
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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VR23 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
VR23 is a chloroquine derivative that functions as a proteasome inhibitor (IC
50s = 1 nM, 50-100 nM, and 3 μM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively). It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells. In combination with the chymotrypsin-like proteasome inhibitor bortezomib , VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.
Verwenden
VR23 is a quinoline-sulfonyl hybrid proteasome inhibitor which is used in cancer therapeutics. Targets cancer via cycline E-mediated centrosome.
VR23 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
VR23 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 106)Lieferanten
- VR23
- 7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline
- VR23(VR-23)
- 7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline
- CS-1579
- Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-
- VR23 >=98% (HPLC)
- VR23, 10 mM in DMSO
- VR23[SML1599]
- VR23 ，S7933
- 1624602-30-7
- C19H16ClN5O6S
