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CCF-642

CCF-642 Struktur
346640-08-2
CAS-Nr.
346640-08-2
Englisch Name:
CCF-642
Synonyma:
CCF-642;AC1LYELL;CCF642 ,S8281;CCF 642, ≥98%;CCF 642;CCF-642;CCF642 >=98% (HPLC);CCF642, 10 mM in DMSO;CCF 642;CCF-642;AC1LYELL;3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-
CBNumber:
CB13133223
Summenformel:
C15H10N2O4S3
Molgewicht:
378.45
MOL-Datei:
346640-08-2.mol

CCF-642 Eigenschaften

Siedepunkt:
567.3±60.0 °C(Predicted)
Dichte
1.60±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO:14.4(Max Conc. mg/mL);38.05(Max Conc. mM)
pka
-0.70±0.20(Predicted)
Aggregatzustand
powder
Farbe
yellow to orange
InChI
1S/C15H10N2O4S3/c1-21-10-4-2-9(3-5-10)16-14(18)12(24-15(16)22)8-11-6-7-13(23-11)17(19)20/h2-8H,1H3
InChIKey
SPYIETQLOVDJCF-UHFFFAOYSA-N
SMILES
S=C1SC(C(N1C(C=C2)=CC=C2OC)=O)=CC(S3)=CC=C3[N+]([O-])=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  WGK 3
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

CCF-642 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

CCF642 has been used as a protein disulfide isomerase (PDI) inhibitor to study its ability to reduce the expression of endoplasmic reticulum (ER) stress markers and neuroinflammation in the hippocampus of experimental autoimmune encephalomyelitis (EAE) mice.

Biochem/physiol Actions

CCF642 is a cell-permeable protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action that most likely involves PDI active-site CGHCK motifs instead of cysteine known to be targeted by PACMA 31. CCF642 displays anti-multiple myeloma (MM) activity both in cultures in vitro (IC50 <1 μM against murine 5TGM1 and nine human MM lines) and in mice in vivo (10 mg/kg, 3X i.p. per wk) without apparent adverse effects to the animals or being cytotoxic to normal bone marrow (NLBM) cells even at concentrations as high as 6.75 μM. Consistent with PDI′s role in ER protein folding process, CCF642 treatment causes acute ER stress accompanied by apoptosis-inducing calcium release in MM cells.

CCF-642 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CCF-642 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 91)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5745 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
+86-86-22-87899925 +86-8618522618860
18522618860@163.com China 694 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32467 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471;
sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39040 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11680 58

346640-08-2()Verwandte Suche:


  • CCF-642
  • 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
  • CCF 642;CCF-642
  • AC1LYELL
  • CCF 642;CCF-642;AC1LYELL
  • 4-Thiazolidinone, 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-
  • CCF642 >=98% (HPLC)
  • CCF 642, ≥98%
  • 3-(4-Methoxyphenyl)-5-((5-nitrothiophen-2-yl)methylene)-2-thioxothiazolidin-4-one
  • calcium,Inhibitor,PDI,CCF642,apoptosis,isomerases,disulfide,myeloma,CCF-642,protein,multiple,release,stress,inhibit,anti-multiple,CCF 642
  • CCF642, 10 mM in DMSO
  • CCF642 ,S8281
  • 346640-08-2
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