Nortriptylin
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- CAS-Nr.
- 72-69-5
- Bezeichnung:
- Nortriptylin
- Englisch Name:
- NORTRIPTYLINE
- Synonyma:
- Aventyl;nortryptyline;C07274;Ateben;Sesaval;Avantyl;lambeck;Lumbeck;Noritren;allegron
- CBNumber:
- CB1317147
- Summenformel:
- C19H21N
- Molgewicht:
- 263.38
- MOL-Datei:
- 72-69-5.mol
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Nortriptylin Eigenschaften
- Schmelzpunkt:
- 58 °C
- Siedepunkt:
- 396.62°C (rough estimate)
- Dichte
- 0.9790 (rough estimate)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- 4°C, protect from light
- pka
- pKa 9.7 (Uncertain)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- BCS Class
- 1
- InChI
- InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
- InChIKey
- PHVGLTMQBUFIQQ-UHFFFAOYSA-N
- SMILES
- C(NC)C/C=C1/C2=CC=CC=C2CCC2=CC=CC=C2/1
- EPA chemische Informationen
- Nortriptyline (72-69-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Nortriptylin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Nortriptyline is a drug with a relatively short latent period of action. It is
practically devoid of sedative effects. It is used in manic-depressive psychoses, in all forms
of endogenous depression, and also in major depressive conditions.
Definition
ChEBI: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Sicherheitsprofil
Poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic fumes of NOx.
Stoffwechsel
Nortriptyline is a secondary amine dibenzocycloheptene TCA as well as the major metabolite of
amitriptyline. Similar to desipramine, nortriptyline appears in mother's milk and is metabolized by CYP2D6 to
the primary amine and by ring hydroxylation to its E-10-hydroxy metabolite. Approximately
one-third of a dose of nortriptyline is excreted in urine as metabolites within 24 hours, and small amounts are
excreted in feces via biliary elimination.
Nortriptylin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nortriptylin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
72-69-5(Nortriptylin)Verwandte Suche:
- 5-(alpha-methylaminopropylidene)dibenzo[a,d]cyclohepta[1,4]diene
- 5-[3-(Methylamino)propylidene]dibenzo[a,E]cyclohepta[1,5]diene
- Noramitriptyline
- Noritren
- Nortryptiline
- Psychostyl
- Sesaval
- NORTRIPTYLINE
- N-[3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLIDENE)PROPYL]-N-METHYLAMINE HYDROCHLORIDE
- 10,11-dihydro-5-(3-methylaminopropylidene)dibenzo(a,d)cycloheptene
- demethylamitryptylene
- demethyl-amitryptylin
- Demethylamitryptyline
- Desitriptilina
- Desmethylamitriptyline
- 10,11-dihydro-5-(3-methylaminopropylidene)-5h-dibenzo[a,d][1,4]cycloheptene
- 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptane-delta,gamma-propylamine
- 10,11-dihydro-n-methyl-5h-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamin
- 10,11-dihydro-n-methyl-5h-dibenzo[a,d]cycloheptene-delta(5,gamma)-propylamine
- 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-
- 1-propanamine,3-(10,11-dihydro-5h-dibenzo(a,d)cycloheptene-5-ylidene)-n-methyl
- Nortrityline
- C07274
- 5h-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine,10,11-dihydro-n-methyl
- 5H-Dibenzo[a,d]cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N-methyl-
- allegron
- Amitryptyline, demethyl-
- Ateben
- Avantyl
- Demethylamitriptylene
- Demethylamitriptyline
- 3-(10,11-dihydro-5h-dibenzo[a,d]-cyclohepten-5-ylidene)-n-methyl-1-propanamine
- 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
- 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n-methylpropylamine
- 5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene
- 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
- lambeck
- Lumbeck
- Amitriptyline EP Impurity C
- NORTRIPTYLINE USP/EP/BP
- nortryptyline
- Aventyl
- Nortriptylene
- c.3-(10,11-dihydro-5h-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine(nortriptyline),
- 72-69-5
- 84-71-3
