3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

622387-85-3

CAS-Nr.: 622387-85-3

Englisch Name:: 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

Synonyma:: OXSI 2;Syk Inhibitor;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation

CBNumber:: CB1364747

Summenformel:: C18H15N3O3S

Molgewicht:: 353.4

MOL-Datei:: 622387-85-3.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 50

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Eigenschaften

Dichte: 1.490±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

storage temp.: Store at -20°C

L?slichkeit: Soluble in DMSO

Aggregatzustand: Orange powder solid.

pka: 9.594±0.20(predicted)

Farbe: Light yellow to brown

Sensitive: Light Sensitive

InChI: 1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)

InChIKey: MLKHXLFEYOOYEY-UHFFFAOYSA-N

SMILES: [S](=O)(=O)(N)c1cc2c(cc1)NC(=O)C2=Cc3c4c([n](c3)C)cccc4

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

WGK Germany	WGK 1
Speicherklasse	11 - Combustible Solids

Bildanzeige (GHS)

Alarmwort

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	P264, P280, P305+P351+P338,P337+P313P
H335	Kann die Atemwege reizen.	Spezifische Zielorgan-Toxizit?t (einmalige Exposition)	Kategorie 3 (Atemwegsreizung)	Warnung

Sicherheit

P261	Einatmen von Staub vermeiden.
P304+P340	BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405	Unter Verschluss aufbewahren.

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC₅₀ value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC₅₀ = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.

Verwenden

OXSI 2 is a Syk selective inhibitor.

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 50)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32468	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30224	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774 400-920-5774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58

Syk Inhibitor
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
OXSI 2
2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide
3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE
1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-
Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
622387-85-3
C18H15N3O3S
pharmacetical
Spleen Tyrosine Kinase Inhibitor

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