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Piroxicam

Piroxicam Struktur
36322-90-4
CAS-Nr.
36322-90-4
Bezeichnung:
Piroxicam
Englisch Name:
Piroxicam
Synonyma:
CB1375282;Feldene;Pipoxicam;Prioxicam;4-HYDROXY-2-METHYL-3-(PYRID-2-YL-CARBAMOYL)-2H-1,2-BENZOTHIAZINE 1,1-DIOXIDE;Baxo;Erazon;Pirkam;Riacen;Zunden
CBNumber:
CB1375282
Summenformel:
C15H13N3O4S
Molgewicht:
331.35
MOL-Datei:
36322-90-4.mol

Piroxicam Eigenschaften

Schmelzpunkt:
198-200°C
Dichte
1.3664 (rough estimate)
Brechungsindex
1.6320 (estimate)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, soluble in methylene chloride, slightly soluble in anhydrous ethanol. It shows polymorphism (5.9).
pka
6.3 (2:1 dioxane-water)
Aggregatzustand
Solid
Farbe
White to Light yellow
Biologische Quelle
synthetic (organic)
Wasserl?slichkeit
Soluble in water, ethanol, chloroform, ethyl acetate.
maximale Wellenl?nge (λmax)
358nm(H2O)(lit.)
Merck 
14,7506
BCS Class
2
Major Application
pharmaceutical (small molecule)
InChI
1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
InChIKey
QYSPLQLAKJAUJT-UHFFFAOYSA-N
SMILES
CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O
CAS Datenbank
36322-90-4(CAS DataBase Reference)
NIST chemische Informationen
Piroxicam(36322-90-4)
EPA chemische Informationen
2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide (36322-90-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,F,T
R-S?tze: 22-25
S-S?tze: 26-36
RIDADR  UN 2811
WGK Germany  3
RTECS-Nr. DL0705000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
STOT RE 2 Oral
Toxizit?t LD50 orally in mice: 360 mg/kg (Wiseman)
Bildanzeige (GHS) Skull and Crossbones (GHS06)Health Hazard (GHS08)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

Piroxicam Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Piroxieam is a non-steroidal anti-inflammatory drug, of the oxieam class. A contact and photocontact sensitizer, which induced contact dermatitis in a physieal therapist. Piroxieam generally cross reacts with thiosalicylic acid and also with thiomersal. Cross sensitivity is not observed to tenoxicam.

Chemische Eigenschaften

Off-White to Pale Yellow Solid

Verwenden

Piroxicam is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, myalgia, and other diseases associated with inflammation.

Indications

Piroxicam (Feldene) is indicated for the treatment of rheumatoid arthritis and osteoarthritis. Piroxicam is a nonspecific COX inhibitor that has a much higher affinity for COX-1 than COX-2. This may account for the large proportion (over 30%) of patients receiving long-term therapy who have reported side effects.Adverse GI reactions have been the most frequently reported side effect, but edema, dizziness, headache, rash, and changes in hematological parameters have also occurred in 1 to 6% of patients. Piroxicam can cause serious GI bleeding, ulceration, and perforation, particularly in the elderly, if the recommended dosage is exceeded or if aspirin is being taken concurrently.

Definition

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine.

Allgemeine Beschreibung

Piroxicam (Feldene) is the most widely used oxicam becauseof its once-daily dosing schedule. It is well absorbedafter oral administration and has a plasma half-life of 50hours, thus requiring a dose of only 20 to 30 mg oncedaily. It undergoes extensive hepatic metabolism, catalyzedby CYP2C9 to give 5-hydroxypiroxicam as its majormetabolite. Several piroxicam prodrugshave been synthesized via derivatization of the enol alcoholgroup (amipiroxicam, droxicam, and pivoxicam) to reducepiroxicam-induced GI irritation.

Biologische Aktivit?t

Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC 50 values for COX-2/COX-1 ~ 600).

Piroxicam Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Piroxicam Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 769)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Liaoning Pharmaceutical Innovation Co., Ltd
+8616588669988
sales@pipharma.com.cn China 151 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 861 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368
sales@sjar-tech.com China 529 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+86-15350851019; +8615350851019
admin@86-ss.com China 999 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 880 50
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60

36322-90-4(Piroxicam)Verwandte Suche:


  • 4-HYDROXY-2-METHYL-3-(PYRID-2-YL-CARBAMOYL)-2H-1,2-BENZOTHIAZINE 1,2-DIOXIDE
  • 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE
  • 4-hydroxy-2-methyl-n-2-pyridinyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide
  • 3,4-DIHYDRO-2-METHYL-4-OXO-N-2-PYRIDYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE
  • AURORA KA-6753
  • 4-Hydroxy-2-Methyl-1,2-Benzothiazine-3-Carboxylic Acid Ethylester-1,1-Dioxide
  • Piroxicam, Feldene
  • PIROXICAM ASSAY STANDARD BP(CRM STANDARD)
  • PIROXICAM EPP(CRM STANDARD)
  • PIROXICAM USP EP
  • PIROXICAM USP(CRM STANDARD)
  • PIROXICAM(RG)
  • 4-HYDROXY-2-METHYL-N-2-PYRIDINYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE(PIROXICAM)
  • PIROXICAM
  • PIROXICAMUM
  • 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide
  • 2h-1,2-benzothiazine-3-carboxamide,4-hydroxy-2-methyl-n-2-pyridinyl-,1,1-diox
  • 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid
  • 4-hydroxy-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide-1,1-diox
  • 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
  • Artroxicam
  • Baxo
  • Bruxicam
  • Caliment
  • chf1251
  • CP 16171
  • cp16171
  • Erazon
  • Flogobene
  • Geldene
  • Improntal
  • Larapam
  • Pirkam
  • Piroflex
  • piroftal
  • piroxicamusp
  • pyroxycam
  • Reudene
  • Riacen
  • Roxicam
  • Roxiden
  • Sasulen
  • Solocalm
  • Zunden
  • PiroxicaMbcd
  • Piroxicam (125 mg)
  • 4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-1,2-benzothiazine 1,1-dioxide
  • Piroxicam (200 mg)
  • 4-hydroxy-2-Methyl-1,1-dioxo-N-(pyridin-2-yl)-2H-1$l^{6},2-benzothiazine-3-carboxaMide
  • PiroxicaMUSP30
  • 4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-2H-1,2-benzothiazine 1,1-Dioxide 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide
  • piroxicaM us
  • 4-Hydroxy-2-Methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxaMide 1,1-dioxide
  • 4-hydroxy-2-methyl-N-2-pyridinyl-1,1-dioxide-2H-1,2-benzothiazine-3-carboxamide
  • Piroxicam Solution, 100ppm
  • Piroxicam 36322-90-4
  • 4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
  • piroxicam pyroxycam roxicam piroxicam usp
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