DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
|
|
|
- CAS-Nr.
- 53016-31-2
- Englisch Name:
- DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- Synonyma:
- RWJ 10553;BRN 4202099;levonorgestreloxime;D-Norgestrel 3-oxime;(-)-NorelgestroMin-d6;Desacetylnorgestimate;17-Deacylnorgestimate;Levonorgestrel 3-oxime;Norgestimate Impurity C; 17-Deacetylnorgestimate
- CBNumber:
- CB1500552
- Summenformel:
- C21H29NO2
- Molgewicht:
- 327.46
- MOL-Datei:
- 53016-31-2.mol
|
DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Eigenschaften
- Schmelzpunkt:
- 107-109°C
- Siedepunkt:
- 491.9±45.0 °C(Predicted)
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMF: 11 mg/ml; DMSO: 10 mg/ml; Ethanol: 12 mg/ml; PBS (pH 7.2): 0.25 mg/ml
- Aggregatzustand
- A solid
- pka
- 12.22±0.60(Predicted)
- Farbe
- White to off-white
- CAS Datenbank
- 53016-31-2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
|
P201, P202, P281, P308+P313, P405,P501 |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
|
|
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
|
DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ortho Evra@ is the first birth control transdermal patch and contains a combination of
norelgestromin and ethinylestradiol. The patch can be applied to the buttocks, lower
abdomen, upper torso or arms; changed weekly for 3 weeks, followed by a patch-free
week. Norelgestromin is the active metabolite produced following oral administration of
norgestimate, the progestin component of the contraceptive, Ortho-Cyclen
. The half-life
value of norelgestromin was approximately 28 h. Following application, norelgestromin
rapidly appeared in the serum, reached a plateau by approximately 48h and was
maintained at an approximate steady state throughout the wear period. Hepatic
metabolites of norelgestromin included norgestrel and various hydroxylated and conjugated metabolites that were eliminated by renal and fecal pathways. Ortho Evra
produced ovarian suppression and cycle control. It was significantly more effective in
suppressing follicular development than the leading oral contraceptive Triphasil
(ethinyl
estradiol/levomorgestrel); was as effective in preventing pregnancies and had similar
tolerability profile. The patch offers 99% efficacy when used appropriately, as shown by
three clinical trials. However, a statistically significantly greater proportion of pregnancies
occurred among women weighing 90 kg or more. Ortho Evra
was well tolerated, with
2.6% of women discontinuing treatment due to mild to moderate reactions at the site of
application. Thus, the patch combined the efficacy of oral contraceptives with the
convenience of just once-weekly dosing.
Chemische Eigenschaften
White Solid
DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 72)Lieferanten
53016-31-2()Verwandte Suche:
- (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one OxiMe
- (17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one-d6 OxiMe
- (-)-NorelgestroMin-d6
- (17alpha)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime
- (E)- and (Z)-17-Deacetylnorgestimate mixture
- Norgestimate metabolite Norelgestromin
- 17-Desacetyl Norgestimate ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- Deacetylnorgestimate (Mixture of (E)- And (Z)-17-Deacetyl Norgestimate)
- (17R)-13-Ethyl-17-hydroxy-18,19-dinor-pregna-4-ene-20-yne-3-oneoxime
- [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one oxime
- [17R,(+)]-17-Hydroxy-13-ethyl-18,19-dinorpregna-4-ene-20-yne-3-oneoxime
- Desacetylnorgestimate
- DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)
- ,10-alpha,13-alpha,14-beta)-
- 18,19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,oxime,(8-alpha,9-beta
- levonorgestreloxime
- 17-Deacetylnorgestimate
- (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one Oxime
- 18-Methylnorethindrone oxime
- BRN 4202099
- D-Norgestrel 3-oxime
- Levonorgestrel 3-oxime
- RWJ 10553
- 13-ETHYL-17_-HYDROXY-18,19-DINORPREGN-4-EN-20-YN-3-ONE OXIME
- 17-Desacetyl Norgestimate Solution, 100ppm
- 17-Desacetyl Norgestimate (Mixture of Isomers)
- 17-Deacylnorgestimate
- 17-Desacetyl Norgestimate-d7 (Mixture ofIsomers) (Norelgestromin-d7)
- 17-Desacetyl Norgestimate (Mixture of Isomers) (Norelgestromin)
- 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, oxime, (17α)-
- (E/Z)-17-Deacetylnorgestimate
- 17-Desacetyl NorgestimateQ: What is
17-Desacetyl Norgestimate Q: What is the CAS Number of
17-Desacetyl Norgestimate Q: What is the storage condition of
17-Desacetyl Norgestimate Q: What are the applications of
17-Desacetyl Norgestimate
- Norelgestromin (1468454)
- Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture) (1471958)
- Deacetylnorgestimate (Mixture of (E)- And (Z))
- Drug Metabolite,inhibit,Inhibitor,Norgestimate metabolite Norelgestromin
- Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture)
- (8R,9S,10R,13S,14S,17R,E)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime
- Deacetylnorgestimate (25 mg) ((E)- and (Z)-17-deacetyl norgestimate mixture) (PLANNED TO BE DISCONTINUED)
- Norgestimate metabolite Norelgestromin (mixture of isomers)
- Norelgestromin (17-Deacetylnorgestimate)
- Norgestimate metabolite Norelgestromin, 10 mM in DMSO
- Norgestimate EP Impurity C and Norgestimate EP Impurity D (17-Desacetyl Norgestimate, Norelgestromin)
- Norgestimate Impurity C
- 53016-31-2
- Various Metabolites and Impurities
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Steroids
