DOFETILIDE-D4
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- CAS-Nr.
- 1189700-56-8
- Englisch Name:
- DOFETILIDE-D4
- Synonyma:
- Tikosyn-d;Tikosyn-d4;UK 68789 D4; UK-68798-d4;DOFETILIDE-D4;N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide-d4;N-[4-(2-{[2-(4-methanesulfonamidophenoxy)(1,1,2,2-2H?)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide;Dofetilide D4Q: What is
Dofetilide D4 Q: What is the CAS Number of
Dofetilide D4 Q: What is the storage condition of
Dofetilide D4 Q: What are the applications of
Dofetilide D4
- CBNumber:
- CB1648928
- Summenformel:
- C19H27N3O5S2
- Molgewicht:
- 441.56478
- MOL-Datei:
- 1189700-56-8.mol
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DOFETILIDE-D4 Eigenschaften
- Schmelzpunkt:
- 130-1350C
- storage temp.
- -20°C Freezer
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White
- CAS Datenbank
- 1189700-56-8
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
DOFETILIDE-D4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Dofetilide-d
4 is intended for use as an internal standard for the quantification of dofetilide by GC- or LC-MS. Dofetilide is a class III antiarrhythmic agent that prolongs cardiac action potential duration by selectively inhibiting the rapidly activating inward rectifying component of net delayed rectifier K
+ current (IC
50 = 31.5 nM in guinea pig cardiomyocytes). However, at 1 μM, dofetilide has pro-arrhythmic activity, inducing early afterdepolarizations (prolonged repolarization) in cell models and Torsade de Pointes in a rabbit screen for proarrhythmic properties when administered at a dose of 10 mg/kg. Formulations containing dofetilide have been used in the treatment of highly symptomatic atrial fibrillation and the conversion of flutter to normal sinus rhythm.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Dofetilide-d4 is intended for use as an internal standard for the quantification of Dofitilide by GC- or LC-mass spectrometry.
DOFETILIDE-D4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DOFETILIDE-D4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 42)Lieferanten
1189700-56-8()Verwandte Suche:
- DOFETILIDE-D4
- UK-68798-d4
- N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-methanesulfonamide-d4
- Tikosyn-d
- Tikosyn-d4
- UK 68789 D4
- Dofetilide D4Q: What is
Dofetilide D4 Q: What is the CAS Number of
Dofetilide D4 Q: What is the storage condition of
Dofetilide D4 Q: What are the applications of
Dofetilide D4
- N-[4-(2-{[2-(4-methanesulfonamidophenoxy)(1,1,2,2-2H?)ethyl](methyl)amino}ethyl)phenyl]methanesulfonamide
- 1189700-56-8
- C19H23D4N3O5S2
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Pharmaceuticals
- Sulfur & Selenium Compounds
- Isotope Labelled Compounds
