(5α,25R)-Spirostan-3β-ol
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- CAS-Nr.
- 77-60-1
- Bezeichnung:
- (5α,25R)-Spirostan-3β-ol
- Englisch Name:
- Tigogenin
- Synonyma:
- Ticogenin;Nsc93754;TIGOGENIN;Sisalagenin;TIGOGENIN90%;Tigogenin-RM;Sisal saponin;SMILAGENIN(RG);Trigonegenin B;Tsosarsasaprgein
- CBNumber:
- CB1669512
- Summenformel:
- C27H44O3
- Molgewicht:
- 416.64
- MOL-Datei:
- 77-60-1.mol
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(5α,25R)-Spirostan-3β-ol Eigenschaften
- Schmelzpunkt:
- 202-204°C
- alpha
- -68 º (c=0.8g/100ml, CHCl3)
- Siedepunkt:
- 474.91°C (rough estimate)
- Dichte
- 1.0362 (rough estimate)
- Brechungsindex
- 1.4700 (estimate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- L?slichkeit
- Chloroform (Slightly)
- Aggregatzustand
- Solid
- pka
- 15.14±0.70(Predicted)
- Farbe
- Off-White
- Optische Rotation
- -67.218 (c 1, CHCl3)
- InChIKey
- GMBQZIIUCVWOCD-YBQFXAOSNA-N
- CAS Datenbank
- 77-60-1(CAS DataBase Reference)
- NIST chemische Informationen
- Tigogenin(77-60-1)
Sicherheit
(5α,25R)-Spirostan-3β-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tigogenin is a steroidal sapogenin that has been found in
A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers
Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus
A. fumigatus (MIC
50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.
Chemische Eigenschaften
mp 196-208C° LOD ≤0.5%
Verwenden
Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.
(5α,25R)-Spirostan-3β-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(5α,25R)-Spirostan-3β-ol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 257)Lieferanten
77-60-1((5α,25R)-Spirostan-3β-ol)Verwandte Suche:
- TIGOGENIN
- (25r)-5-alpha-spirostan-3-beta-o
- 25R,5ALPHA-SPIROSTAN-3BETA-OL
- 5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL
- (25R)-5-Spirostan-3-ol
- (3-beta,5-alpha,25r)-spirostan-3-o
- 5-alpha-spirostan-3-beta-ol
- 5alpha-Spirostan-3beta-ol, (25R)-
- Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran], spirostan-3-ol deriv.
- Spirostan-3-ol, (3beta,5alpha,25R)-
- Tsosarsasaprgein
- (5alpha,25R)-spirostan-3beta-ol
- TIGOGENIN90%
- SMILAGENIN(RG)
- (3,5,25R)-3-Hydroxy-spirostane
- (3-beta,5-alpha,25r)-spirostan-3-ol
- TIGOGENIN (91%: 95%) (5A,25R)-SPIROSTAN-3B-OL)
- Sisalagenin
- (25R)-5a-Spirostan-3b-ol
- (25R)-3β-Hydroxy-5α-spirostane
- Trigonegenin B
- Nsc93754
- 22-Isoallospirostan-3β-ol
- (2aS,2'R,4S,5'R,6aS,6bS,8aS,8bR,9S,11aS,12aS,12bR)-5',6a,8a,9-TetraMethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
- (25R)-5.α.-Spirostan-3.β.-ol
- (2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
- 5α, 20α, 22α, 25D-SPIROSTAN-3β-OL
- Sisal saponin
- Tigogenin-RM
- (2a-S,4S,5'R,6a-S,6b-S,8a-S,8b-R,9S,10R,1a-S,12a-S,12b-R)-5',6a,8a,9-tetramethyldidecadihydrospiro[naphthalenebenzo[2',1':4,5]benzo[2,1-b]furan-10,2'-pyran]-4-ol
- Tigogenin (Standard)
- Ticogenin
- 77-60-1
- Miscellaneous Natural Products
