Pregnenolon
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- CAS-Nr.
- 145-13-1
- Bezeichnung:
- Pregnenolon
- Englisch Name:
- Pregnenolone
- Synonyma:
- 3β-Hydroxypregn-5-en-20-one;Pregnelone;prenenolone;5-pregnen-3B-ol-20-one;5-pregnen-3β-ol-20-one;DELTA5-PREGNEN-3BETA-OL-20-ONE;5-Preg;ZK-5553;-20-one;prenolon
- CBNumber:
- CB1684326
- Summenformel:
- C21H32O2
- Molgewicht:
- 316.48
- MOL-Datei:
- 145-13-1.mol
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Pregnenolon Eigenschaften
- Schmelzpunkt:
- 188-190 °C
- alpha
- 28.5 º (c=1, EtOH)
- Siedepunkt:
- 395.89°C (rough estimate)
- Dichte
- 1.0382 (rough estimate)
- Dampfdruck
- 0-0Pa at 20-25℃
- Brechungsindex
- 1.5344 (estimate)
- Flammpunkt:
- 9℃
- storage temp.
- Refrigerator
- L?slichkeit
- ethanol: soluble10mg/mL, clear, colorless to faintly yellow
- Aggregatzustand
- Powder
- pka
- 15.00±0.70(Predicted)
- Farbe
- White to off-white
- Wasserl?slichkeit
- 41mg/L(room temperature)
- Merck
- 7733
- BRN
- 2059026
- Major Application
- clinical testing
clinical testing
- InChI
- 1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
- InChIKey
- ORNBQBCIOKFOEO-QGVNFLHTSA-N
- SMILES
- O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)C)(CC3)C)CC=C2C1)C
- LogP
- 4.4 at 20℃
- CAS Datenbank
- 145-13-1(CAS DataBase Reference)
- NIST chemische Informationen
- Pregnenolone(145-13-1)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
22-24/25 |
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| RIDADR |
UN 1648 3 / PGII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TU5560700 |
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| HS Code |
29372900 |
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| Speicherklasse |
3 - Flammable liquids |
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| Hazard Classifications |
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
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P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Pregnenolon Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Pregnenolone serves as the common precursor in the formation of the adrenocorticoids and other steroid
hormones. This C21 steroid is converted via enzymatic oxidations and isomerization of the double bond to a
number of physiologically active C21 steroids, including the female sex hormone progesterone and the
adrenocorticoids hydrocortisone (cortisol), corticosterone, and aldosterone. Oxidative cleavage of the
two-carbon side chain of pregnenolone and subsequent enzymatic oxidations and isomerization lead to C19
steroids, including the androgens testosterone and dihydrotestosterone. The final group of steroids, the C18
female sex hormones, are derived from oxidative aromatization of the A ring of androgens to produce estrogens.
Chemische Eigenschaften
white to off-white powder
Verwenden
Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA an
tagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A
Definition
ChEBI: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
Allgemeine Beschreibung
Pregnenolone is an endogenous steroid hormone involved in the biological synthesis of other hormones. Pregnenolone is monitored as an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations where diagnosis of 21-hydroxylase and 11-hydroxylase deficiency has been ruled out. This Certified Spiking Solution
is suitable for use in LC-MS/MS testing methods as a starting material in the preparation of calibrators, controls and linearity standards.
Nebenwirkungen
When taken by mouth: Pregnenolone is possibly safe when used for up to 12 weeks. It is usually well-tolerated. Side effects might include acne, agitation, diarrhea, drowsiness, excitement, hair loss, skin rashes, sweating, and tremor. There isn't enough reliable information to know if pregnenolone is safe when used for longer than 12 weeks.
Pregnenolon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
3-β-Hydroxypregna-5,16-dien-20-on
Pregna-5,17(20)-diene-3,20-diol,diacetate, (3b)- (9CI)
Pregn-5-en-20-one,3-hydroxy-, cyclic 1,2-ethanediyl dithioacetal, (3b)- (9CI)
Difluoromethyldiphenylphosphine Oxide
Pregnenolonacetat
20ALPHA-HYDROXYCHOLESTEROL
3-tert-Butyldimethylsilyloxy Pregnenolone
Bromomethyl methyl ether
Stigmast-5-en-3-β-ol
20-Oxopregna-5,16-dien-3-β-ylacetat
Downstream Produkte
Pregnenolon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 593)Lieferanten
145-13-1(Pregnenolon)Verwandte Suche:
- PREGNENOLONE(RG)
- PREGNENOLONE(3BETA-HYDROXYPREGN-5-EN-20-ONE)
- Progeserone
- Pregnenolone
5-Pregnenolone
- pregnenolone solution,100ppm
- Pregnenolone 0
- Pregnenolone/Pregnenolone acetate
- 3β-Hydroxy-5-pregnen-20-one, 5-Pregnen-3β-ol-20-one
- 3β-Hydroxy-5-pregnen-20-one, Pregnenolone
- ZK-5553
- Pregnenolone,99%
- Pregnenolone3beta-Hydroxy-5-pregnen-20-one
- PREGNENOLONE(P)
- DELTA5-PREGNEN-3B-OL-20-ONE
- DELTA-5-PREGNENE-3B-OL-20-ONE
- DELTA5-PREGNENOLONE
- 3BETA-HYDROXY-5-PREGNEN-20-ONE
- 3BETA-HYDROXYPREGN-5-EN-20-ONE
- 3b-hydroxy-5-pregnen-20-one
- 5-pregnenolone
- 5-PREGNEN-3BETA-OL-20-ONE
- PREGNENOLONE
- prenolon
- pregnolon
- 1-((3S,8S,9S,10R,13S,14S,17S)-3-HYDROXY-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-ETHANONE
- (3-beta)-pregn-5-en-20-on
- 3-beta-hydroxy-pregn-5-en-20-on
- Pregnenlolone
- Pregnenolone Micron
- 3Hydroxy-5-Pregnen-20-one
- 1-[(3S,8S,9S,10R,13S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
- 3β-hydroxy-pregn-5-ene-20-one
- 4-(4-methylphenyl)-3,5-diphenyl-1,2,4-triazole
- 1-[(3S,8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-hydroxy-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
- Pregnenolone solution
- -20-one
- 5-Preg
- nen-3β-oL
- fast-shipping Pregnenolone
- Pregnenolone>
- Pregnenolone (3beta-Hydroxypregn-5-
- Arthenolone
- Pregn-5-en-20-one, 3-hydroxy-, (3β)-
- 5-Pregnen-3β-oL
- High quality Pregnenolone
- prenenolone
- DELTA5-PREGNEN-3BETA-OL-20-ONE
- 5-pregnen-3B-ol-20-one
- 3β-Hydroxy-5-pregnen-20-one
- (3β)-3-Hydroxypregn-5-en-20-one
- Pregnenolon : 3beta-Hydroxypregn-5-en-20-on
- 1-((3S,8S,9S,10R,13S,14S,17S)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
- Pregnenolone in Methanol
- Pregnenolone, 10 mM in DMSO
- Pregnenolone 0.1 mg/ml in Acetonitrile
- 16,16-D2-Pregnenolone
- pregnaneneolone
- Pregnenolone (3β-Hydroxypregn-5-en-20-one)
