4-IODO-6-PHENYLPYRIMIDINE
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- CAS-Nr.
- 41270-96-6
- Englisch Name:
- 4-IODO-6-PHENYLPYRIMIDINE
- Synonyma:
- 4-IPP;4-IPP, 10 mM in DMSO;MIF Antagonist III, 4-IPP;4-IODO-6-PHENYLPYRIMIDINE;Pyrimidine, 4-iodo-6-phenyl-;4-IPP (4-Iodo-6-phenylpyrimidine);MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem;Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
- CBNumber:
- CB1686643
- Summenformel:
- C10H7IN2
- Molgewicht:
- 282.08
- MOL-Datei:
- Mol file
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4-IODO-6-PHENYLPYRIMIDINE Eigenschaften
- Siedepunkt:
- 380.2±30.0 °C(Predicted)
- Dichte
- 1.728±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble10mg/mL (clear solution, warmed)
- pka
- -0.54±0.17(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
- InChIKey
- ZTCJXHNJVLUUMR-UHFFFAOYSA-N
- SMILES
- Ic1cc(ncn1)-c2ccccc2
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22-37/38-41 |
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| S-S?tze: |
26-39 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
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P280, P305+P351+P338, P310 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-IODO-6-PHENYLPYRIMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for
in vitro migration assay.
Biologische Aktivit?t
Inhibitor of macrophage migration inhibitor factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo . Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro .
Biochem/physiol Actions
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
4-IODO-6-PHENYLPYRIMIDINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-IODO-6-PHENYLPYRIMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 75)Lieferanten
- 4-IODO-6-PHENYLPYRIMIDINE
- MIF Antagonist III, 4-IPP
- MIF Antagonist III, 4-IPP - CAS 41270-96-6 - Calbiochem
- Pyrimidine, 4-iodo-6-phenyl-
- 4-IPP (4-Iodo-6-phenylpyrimidine)
- Inhibitor,osteoclastogenesis,4IPP,MIF,4-IPP,inhibit,4 IPP,RANKL,osteoblast
- 4-IPP, 10 mM in DMSO
- 4-IPP
- 41270-96-6
