Bilobalide
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- CAS-Nr.
- 33570-04-6
- Englisch Name:
- Bilobalide
- Synonyma:
- (-)-BILOBALIDE;Bilobalide A;BILOBALID;BILOBALIDE;VITEXICARPIM;Ginkgolactone;Bilobalide(P);BILOBALIDE(SH);Bilobalide >Bilobalide(AS)
- CBNumber:
- CB1688713
- Summenformel:
- C15H18O8
- Molgewicht:
- 326.3
- MOL-Datei:
- 33570-04-6.mol
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Bilobalide Eigenschaften
- Schmelzpunkt:
- >300°
- alpha
- 57820 -64.3° (c = 2 in acetone)
- Siedepunkt:
- 651.7±55.0 °C(Predicted)
- Dichte
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- L?slichkeit
- Acetone (Slightly), Methanol (Slightly)
- pka
- 11.74±0.40(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Biologische Quelle
- plant leaves (Ginkgo biloba)
- Merck
- 14,1220
- Stabilit?t:
- Hygroscopic
- Major Application
- food and beverages
- InChI
- InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
- InChIKey
- MOLPUWBMSBJXER-YDGSQGCISA-N
- SMILES
- O1C(=O)[C@]23CC(=O)O[C@@]2([H])C[C@](C(C)(C)C)(O)[C@]23[C@@H](O)C(=O)O[C@@]12[H]
- LogP
- -0.450 (est)
- CAS Datenbank
- 33570-04-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
LV1665000 |
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| F |
10 |
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| HS Code |
29322090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
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P280, P305+P351+P338, P310 |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Bilobalide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bilobalide is a sesquiterpene lactone which is found in extracts of
G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
Verwenden
Reference Standard in the analysis of herbal medicinal products
Definition
ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
Allgemeine Beschreibung
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Enzyminhibitor
This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.
Bilobalide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Bilobalide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 380)Lieferanten
33570-04-6()Verwandte Suche:
- BILOBALID
- 4H,5aH,9H-Furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione, 9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-, (3aS,5aR,8R,8aS,9R,10aS)-
- BILOBALIDE
- 5,3'-DIHYDROXY-3,6,7,4'-TETRAMETHOXYFLAVONE
- 4H,5AH,9H-FURO[2,3-B]FURO[3',2':2,3]CYCLOPENTA[1,2-C]FURAN-2,4,7(3H,8H)-TRIONE,9-(1,1-DIMETHYLETHYL)-10,10A-DIHYDRO-8,9-DIHYDROXY-, [5AR-(3AS*,5A,8,8AS*,9,10A)]-
- 3',5-DIHYDROXY-3,4',6,7-TETRAMETHOXY FLAVONE
- VITEXICARPIM
- BILOBALIDE(SH)
- 4H,5aH,9H-Furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)-trione,9-(1,1-dimethylethyl)-10,10a-dihydro-8,9-dihydroxy-,[5aR-(3aS*,5aα,8β,8aS*,9α,10aα)]-
- (-)-bilobalidefromginkgoleaves
- BILOBALIDE: 4H,5AH,9H-FURO[2,3-B]FURO[3',2':2,3]CYCLOPENTA[1,2-C]FURAN-2,4,7(3H,8H)-TRIONE,9-(1,1-DIMETHYLETHYL)-10,10A-DIHYDRO-8,9-DIHYDROXY-, [5AR-(3AS*,5A,8,8AS*,9,10A)]-,
- (-)-bilobalide from ginkgo biloba leaves
- BILOBALIDE(AHP)
- (-)-Bilobalide, froM Ginkgo biloba
- (5AR- (3AS*,5AΑ,8B,8AS*,9A,10AΑ))- 9-(1,1-DIMETHYLETHYL)- 10,10A-DIHYDRO- 8,9-DIHYDROXY- 4H,5AH,9H-FURO[2,3-B]FURO[3',2':2,3]CYCLOPENTA[1,2-C]FURAN- 2,4,7(3H,8H)-TRIONE
- (-)-Bilobalide, 98%, from Ginkgo biloba L.
- Bilobalide 33570-04-6
- Bilobalide >
- Bilobalide USP/EP/BP
- (-)-bilobalide from ginkgo leaves
- -Amino-2-methyl-40H-tetrazole
- Ginkgolactone
- (?)-Bilobalide from Ginkgo biloba leaves
- (-)-Bilobalide-RM
- Bilobalide(AS)
- Bilobalide(P)
- (?)-Bilobalide from Ginkgo biloba leaves
- Bilobalide (Standard)
- (-)-BILOBALIDE
- Bilobalide A
- 33570-04-6
- C15H18O9
- C15H18O8
- Inhibitors
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Heterocycles
- Biochemicals Found in Plants
- Isoprenoid/terpenoid
- Nutrition Research
