Fumonisin B1
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- CAS-Nr.
- 116355-83-0
- Bezeichnung:
- Fumonisin B1
- Englisch Name:
- FUMONISIN B1
- Synonyma:
- FB1;MACROFUSINE;FUMONISIN B1;B1 Fumonisin B1;Fumonisin B1,96%;FUMONISIN B1 98%;Fumonisin B1 ,95%;Fumonisin B1
(FB1);fumonisin b1solution;FuMonisin B1, 96% 1MG
- CBNumber:
- CB1773259
- Summenformel:
- C34H59NO15
- Molgewicht:
- 721.83
- MOL-Datei:
- 116355-83-0.mol
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Fumonisin B1 Eigenschaften
- Schmelzpunkt:
- >60oC
- Siedepunkt:
- 713.81°C (rough estimate)
- Dichte
- 1.2207 (rough estimate)
- Brechungsindex
- 1.6630 (estimate)
- Flammpunkt:
- 6 °C
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in Water (up to 25 mg/ml).
- Aggregatzustand
- Powder
- pka
- 3+-.0.23(Predicted)
- Farbe
- White to tan
- Biologische Quelle
- Fusarium sp. (Fusarium moniliforme)
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
- InChIKey
- GPIYLYZFGAXYSU-UHFFFAOYSA-N
- SMILES
- C(CC(C)CC(O)CCCCC(O)CC(O)C(N)C)(OC(=O)CC(C(=O)O)CC(=O)O)C(CC(C)CCC)OC(=O)CC(C(=O)O)CC(=O)O
- CAS Datenbank
- 116355-83-0
- IARC
- 2B (Vol. 56) 1993, 2B (Vol. 82) 2002
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn,T,F |
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| R-S?tze: |
40-36-20/21/22-11 |
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| S-S?tze: |
36/37-16-26-45 |
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| RIDADR |
3172 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
TZ8350000 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
29221990 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral
Carc. 2
Repr. 2
STOT RE 2 |
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| Giftige Stoffe Daten |
116355-83-0(Hazardous Substances Data) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H373 |
Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
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Fumonisin B1 Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R36:Reizt die Augen.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Chemische Eigenschaften
white to tan powder
Verwenden
Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons.
Allgemeine Beschreibung
Fumonisin B
1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC
50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB
1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
Biologische Aktivit?t
Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively.
Fumonisin B1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fumonisin B1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 210)Lieferanten
116355-83-0(Fumonisin B1)Verwandte Suche:
- MACROFUSINE
- FUMONISIN B1
- FUMONISIN B1, FUSARIUM MONILIFORME
- 1,2,3-PROPANETRICARBOXYLIC ACID 1,1'-[1-(12-AMINO-4,9,11-TRIHYDROXY-2-METHYLTRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANEDIYL] ESTER
- 1,2,3-PROPANETRICARBOXYLIC ACID 1,1'-[12-AMINO-4,9,11-TRIHYDROXY-2-METHYLTRIDECYL)-2-(1-METHYLPENTYL)-1,2-ETHANEDIYL]ESTER
- 1,2,3-propanetricarboxylicacid,1,1’-(1-(12-amino-4,9,11-trihydroxy-2-methyltr
- idecyl)-2-(1-methylpentyl)-1,2-ethanediyl)ester
- FUMONISIN B1 (MACROFUSINE) \ SPHINGOSINE
- FUMONISIN B1 FROM FUSARIUM MONILIFORME
- 1,2,3-Propanetricarboxylic acid, 1,1[1-(12-amino-4,9,11-trihydroxy-2-methyl-tridecyl)-2-(1-methylpentyl)-1,2-ethane-diyl]ester, Macrofusine
- FumonisinB1 from Fusarium moniliforme, Macrofusine
- Fumonisin B1,96%
- 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylicacidester.
- Fumonisin B1 ,95%
- FuMonisin B1, 96% 1MG
- (2R,2'R)-1,2,3-Propanetricarboxylic Acid 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-AMino-4,9,11-trihydroxy-2-Methyltridecyl]-2-[(1R)-1-Methylpentyl]-1,2-ethanediyl] Ester
- FUMONISIN B1 98%
- 1,2,3-Propanetricarboxylic acid, 1,1-(1S,2R)-1-(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl-2-(1R)-1-methylpentyl-1,2-ethanediyl ester, (2R,2R)-
- fumonisin b1solution
- Fumonisin B1 (2R,2'R)-1,2,3-Propanetricarboxylic acid 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester
- Standard Solution Fumonisin B1
- Fumonisin B1
(FB1)
- Fumonisin B, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem
- Fumonisin B1 Ready Made Solution
- Fumonisin B1, 96%, from Fusarium moniliforme
- Fumonisin B1 Solution [ 50μg/ml Acetonitrile:Water(1:1) Solution]
- Fumonisin B1 50ug /ml in ACN:H2O 1:1
- B1 Fumonisin B1
- (2R)-2-(2-{[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-{[(3R)-3,4-dicarboxybutanoyl]oxy}-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy}-2-oxoethyl)butanedioic acid
- Fumonisin B1 50 μg/ml Acetonitrile/Water
- Fumonisine B1 in Acetonitrile:Water=1:1
- Fumonisine B1 in Acetonitrile
- FumonisinB1 standard substance
- Fumonisin B1 from Fusarium moniliforme
- Fumonisin B1
- Fumonisin B1, Fusarium moniliforme
- Fumonisin B1 solution
- Fumonisin B?, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem[344850-1MG]
- Fumonisin B?, Fusarium moniliforme - CAS 116355-83-0 - Calbiochem[344850]
- FB1
- 116355-83-0
- C34H59NO15
- Biochemicals and Reagents
- BioChemical
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors
- R to Z
- Sphingosine N-acyltransferase
- antibiotic
- Miscellaneous Natural Products
- Amines
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
