Phenoxybenzamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Antihypertensive.
Application
Phenoxybenzamine has been the standard agent for blockade before adrenalectomy for pheochromocytoma. However, high cost and limited availability have hampered its use. Selective alpha blockers and calcium channel blockers are increasingly used
[1].
Weltgesundheitsorganisation (WHO)
Phenoxybenzamine, a long-acting alpha-adrenoreceptor
antagonist, was introduced in 1953 and has been used in a variety of peripheral
vascular disorders. In 1982 it was shown to have mutagenic activity and in 1985 it
was found to be carcinogenic in the rat. Its approved use was subsequently
restricted by several regulatory authorities and phenoxybenzamine is currently
used to manage hypertensive episodes associated with phaeochromocytoma, as
an adjunct to the short-term management of urinary retention due to neurogenic
bladder, in the short-term treatment of benign prostatic hypertrophy in patients
awaiting surgery, and in inoperable benign prostatic hypertrophy.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intravenous and intracerebral routes. Moderately toxic by ingestion. Human reproductive effects by ingestion: spermatogenesis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.
l?uterung methode
The free base is crystallised from pet ether, and the HCl is crystallised from EtOH/diethyl ether. [Beilstein 12 IV 2204.]
Phenoxybenzamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
