Vatalanib Dihydrochloride
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- CAS-Nr.
- 212141-51-0
- Englisch Name:
- Vatalanib Dihydrochloride
- Synonyma:
- PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
- CBNumber:
- CB21176854
- Summenformel:
- C20H17Cl3N4
- Molgewicht:
- 419.74
- MOL-Datei:
- 212141-51-0.mol
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Vatalanib Dihydrochloride Eigenschaften
- Schmelzpunkt:
- 268-2700C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
- Aggregatzustand
- solid
- Farbe
- White or off-white
- Wasserl?slichkeit
- H2O: 2mg/mL, clear
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
- InChI
- 1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
- InChIKey
- AZUQEHCMDUSRLH-UHFFFAOYSA-N
- SMILES
- ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42
- CAS Datenbank
- 212141-51-0
Vatalanib Dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC
50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-
Kit (IC
50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-
induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.
Chemische Eigenschaften
White to Off-White Crystalline Powder
Verwenden
Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.
Vatalanib Dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Vatalanib Dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 164)Lieferanten
212141-51-0()Verwandte Suche:
- CGP-79787 Dihydrochlorid
- N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochloride
- Vatalanib Dihydrochloride
- CGP-79787 Dihydrochloride
- Vatalanib 2hcl((ZK-222584,PTK 787)
- Vatalanib dihydrochloride (PTK787)
- CGP-79787
- CGP-79787D
- PTK/ZK
- ZK-222584
- CGP-79787, PTK 787, ZK222584
- N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
- ZK 222584 (cpg-79787) 2HCl
- Vatalanib 2HCl (PTK787)
- Vatalanib (PTK787) 2HCl
- Vatalanib (hydrochloride)
- Vatalanib dihydrochloride(2HCL)
- Vatalanib (PTK787) diHydrochloride
- CS-465
- ZK-222584 dihydrochloride
- CGP-797870 dihydrochloride
- PTK787 dihydrochloride
- Vatalanib Dihydrochloride USP/EP/BP
- 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2)
- CGP79787) 2HCl
- Vatalinib 2HCl
- Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor
- Vatalanib dihydrochloride, 10 mM in DMSO
- Vatalanib dihydrochloride/212141-51-0/98%
- 212141-51-0
- C20H17Cl3N4
- C20H15ClN42HCl
- C20H15Cl2N42HCl
- C20H15ClN42ClH
- Heterocycles
- Tyrosine Kinase Inhibitors
- Antineoplastic
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
