Docarpamine

74639-40-0

CAS-Nr.: 74639-40-0

Englisch Name:: Docarpamine

Synonyma:: TA 870;TA-8704;Tanadopa;Docarpamine;3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine;4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate;(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide;Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester;Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-;Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester

CBNumber:: CB21178560

Summenformel:: C21H30N2O8S

Molgewicht:: 470.54

MOL-Datei:: 74639-40-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 14

Docarpamine Eigenschaften

Schmelzpunkt:: 85-90°; mp 105-108° (Nishiyama, 1992)

alpha: D20 -15.6° (c = 2 in methanol)

Siedepunkt:: 731.0±60.0 °C(Predicted)

Dichte: 1.222±0.06 g/cm3(Predicted)

pka: 14.51±0.46(Predicted)

Sicherheit

Toxizit?t	LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)

Docarpamine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA₁) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.

Verwenden

Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.

Docarpamine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Docarpamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 14)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
RR Scientific LLC	+86-13917743231	sales@rrscientific.com	United States	878	58
Shaanxi Dideu New Materials Co. Ltd	+86-18192503167 18192503167	1036@dideu.com	China	10196	58
SHANGHAI HOHANCE CHEMICAL CO.,LTD	021-31115312 18217084087	mary@hohance.com	China	170	62
Hubei Shishun Biotechnology Co. Ltd	027-59223025 15107168801	1718480011@qq.com	China	9395	58
Hubei Guangao Biotechnology Co., Ltd	027-02702759223056 18162699093	1208480011@qq.com	China	9506	58
Hubei Qifei Pharmaceutical Chemical Co., Ltd	59322506 18071128681	1438082200@qq.com	China	9555	58
R.R Scientific, LLC.	15010167677	zhiyuu1218@163.com	China	876	58
Shaanxi Didu New Material Co., Ltd	81124267 17392282731	1073@dideu.com	China	10000	58
Weifu (Shanghai) Pharmaceutical Technology Co., LTD	021-57609736 13917553503	401919639@qq.com	China	244	58

Docarpamine
Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-
TA 870
Tanadopa
(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide
3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine
TA-8704
Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate
74639-40-0
C21H30N2O8S

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