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SM 5887

SM 5887 Struktur
110311-30-3
CAS-Nr.
110311-30-3
Englisch Name:
SM 5887
Synonyma:
Amrubicin hydrochloride;Calsed;SM 5887;AMR hydrochloride;BHMLHEQFWVQAJS-IERVSNJOSA-N;(1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl2-deoxy-β-D-erythro-pentopyranosidehydrochloride(1:1);(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione·hydrochloride
CBNumber:
CB21374151
Summenformel:
C25H25NO9.ClH
Molgewicht:
519.931
MOL-Datei:
110311-30-3.mol

SM 5887 Eigenschaften

Schmelzpunkt:
145-151°

Sicherheit

Toxizit?t LD50 i.v. in mice: 32-50 mg/kg (Morisada)

SM 5887 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

small and small-cell lung cancers. Amrubicin, a completely synthetic anthracycline derivative, mediates its growth inhibitory action via topoisomerase II inhibition. It is activated in viva by the formation of its 13-OH metabolite, amrubicinol, via reaction with carbonyl reductase. In contrast to doxorubicin and daunorubicin whose metabolites are inactive in the blood, amrubicinol is 10-100 fold more cytotoxic than amrubicin. In phase II clinical trials, amrubicin showed antitumor activity against non-small-cell lung cancers (response rate exceeding 20%) and against untreated extensive stage small-cell-lung cancers (response rate 78.8%). Amrubicin demonstrated a smaller distribution-volume, a shorter half-life in mice and also less chronic cardiotoxicity in preclinical studies compared to doxorubicin. Amrubicin was generally well tolerated with major adverse events being anaemia, leucopenia, thrombocytopenia and neutropenia.

Originator

Sumitomo (Japan)

Trademarks

Calsed

SM 5887 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SM 5887 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 16)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
R&D Scientific Inc.
+1-2266000236
sales@rdscientific.com Canada 1939 58
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
BOC Sciences 16314854226
info@bocsci.com United States 9923 65
Musechem +1-800-259-7612
info@musechem.com United States 4660 60
Shenzhen Botel Biotechnology Co. Ltd. 13316949107 13316968096
1979313431@qq.com China 9584 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946
1461866103@qq.com China 16111 58
Hubei Xinyang Medical Technology Co., Ltd 15347293736
2853117764@yongstandards.com China 9989 58
Hubei wei shi reagent group ltd., company 027-59102966 18717199209
2853877583@qq.com China 2912 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
sales@chemhifuture.com China 6000 58

  • SM 5887
  • (7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione·hydrochloride
  • (1S,3S)-3-Acetyl-3-amino-5,12-dihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl2-deoxy-β-D-erythro-pentopyranosidehydrochloride(1:1)
  • AMR hydrochloride
  • BHMLHEQFWVQAJS-IERVSNJOSA-N
  • Calsed
  • Amrubicin hydrochloride
  • 110311-30-3
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