7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
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- CAS-Nr.
- 199327-61-2
- Englisch Name:
- 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
- Synonyma:
- Gefitinib-8;quinazolin-4(3H);Gefitinib iMpurity F;Gefitinib Impurity 14;Gefitinib Impurity 17;Gefintinib Impurity 5;Getitinib interMediate;Gefitinib impurities135;Gefitinib impurities132;InterMediate of Gefitinib
- CBNumber:
- CB21477111
- Summenformel:
- C16H21N3O4
- Molgewicht:
- 319.36
- MOL-Datei:
- 199327-61-2.mol
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7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Eigenschaften
- Schmelzpunkt:
- 233-236 °C
- Siedepunkt:
- 519.5±60.0 °C(Predicted)
- Dichte
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 7.10±0.10(Predicted)
- Farbe
- White to Off-White
- Major Application
- pharmaceutical
- InChI
- InChI=1S/C16H21N3O4/c1-21-14-10-13-12(16(20)18-11-17-13)9-15(14)23-6-2-3-19-4-7-22-8-5-19/h9-11H,2-8H2,1H3,(H,17,18,20)
- InChIKey
- WFUBWLXSYCFZEH-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(OCCCN3CCOCC3)C(OC)=C2)C(=O)NC=1
- CAS Datenbank
- 199327-61-2(CAS DataBase Reference)
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is a pharmaceutical intermediate used in the preparation of gefitinib, an orally active selective inhibitor of the epidermal growth factor receptor tyrosine kinase, an enzyme that regulates intracellular signalling pathways that associated with the proliferation and survival of cancer cells.
Chemische Eigenschaften
White Solid
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 278)Lieferanten
199327-61-2()Verwandte Suche:
- 7-Methoxy-6-(3-Morpholin-4-ylpropoxy) Quinazolin-
4-(3H)-One Gefitinib HCL InterMediates G5
- Getitinib interMediate
- Gefitinib iMpurity F
- 7-METHOXY-6-(3-MORPHOLINOPROPOXY)QUINAZOLIN-4(3H)-ONE
- 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
- 7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one
- 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone
- Gefitinib Impurity 14
- 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
- 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quainazolin-4(3H)-one
- 6-(3-morpholinopropoxy)-7-methoxyquinazolin-4(3H)-one
- 7-Methoxy-6-(3-morpholinopropoxy)
- quinazolin-4(3H)
- 7-Methoxy-6-(3-morpholin-4-yl-propoxy)-3H-quinazolin-4-one
- 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin
- 7-Methoxy-6-[3-(Morpholin-4-yl)propoxy]-3,4-dihydroquinazolin-4-one
- InterMediate of Gefitinib
- 7-Methoxy-6-(3-Morpholin-4-yl-propoxy) -4-(3H)-quinazolinone
- Gefitinib Impurity 17
- Gefintinib Impurity 5
- Gefitinib-8
- 4(3H)-Quinazolinone, 7-methoxy-6-[3-(4-morpholinyl)propoxy]-
- 7-METHOXY-6-(MORPHOLIN-4-YL PROPY L)QUINAZOLIN-4-(3H)-ONE
- Gefitinib impurities135
- Gefitinib impurities132
- TIANFU-CHEM - 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
- 7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(1H)-one
- 7-methoxy-6- (3-morpholine-4-ylpropyloxy) quinazoline-4 (3H) - one
- 7-Methoxy-6-(3-morpholinopropoxy)quizolin-4(3H)-one
- 7-methoxy-6-(4-morpholinobutyl) quinazolin-4(3H)-one
- [containing < 0.5 % formamide (EC No 200-842-0)]
- [containing ≥ 0.5 % formamide (EC No 200-842-0) ]
- Gefitinib Related Compound A
- Gefitinib EP Impurity A (Gefitinib USP Related Compound A)
- 199327-61-2
- 31936
- Gefitinib INTERMEDIATES
- Heterocycles
- Intermediates
- Intermediates & Fine Chemicals
- Pharmaceuticals
