Methylene boldenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC₅₀ = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC₅₀ = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC₅₀ = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC₅₀ = 2.7 μM) and T47D breast cancer cells (EC₅₀s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.

Chemische Eigenschaften

Off-White Solid

Verwenden

A metabolite of Exemestane; exerts biological effects as an androgen.

Methylene boldenone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methylene boldenone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd.	+undefined18603013401	jack.lin@sincopharmachem.com	China	10000	58
QUALITY CONTROL SOLUTIONS LTD.	+86-0755-66853366 +8613670046396	export03@qcsrm.com	China	24342	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	94642	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50

122370-91-6()Verwandte Suche:

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• METHYLENE BOLDENONE
• (17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
• (17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
• 17--Hydroxy Exemestane
• (17β)-
• 17β-Hydroxy ExeMestane SulfaMate
• Exemestane 17β-Hydroxy Impurity
• Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
• 17β-Hydroxy Exemestane
• (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• Exemestane Impurity 23 (Exemestane EP Impurity H)
• 17beta-Hydroxy-6-methylideneandrosta-1,4-dien-3-one (17beta-Hydroxyexemestane)
• Impurity H in ezetimibe
• 17β-Hydroxy-6-methylideneandrosta-1,4-dien-3-one (17β-Hydroxyexemestane)
• 122370-91-6
• Intermediates & Fine Chemicals
• Metabolites & Impurities
• Pharmaceuticals
• Steroids