1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
|
|
|
- CAS-Nr.
- 203911-27-7
- Englisch Name:
- 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- Synonyma:
- Fasudil 2HCl;HA-1077 (hydrochloride);HA-1077 dihydrochloride solid, >=98% (HPLC);Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:2);1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride;1-(5-Isoquinolinesulphonyl)homopiperazine dihydrochloride salt, Fausidil dihydrochoride salt;HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- CBNumber:
- CB22129608
- Summenformel:
- C14H17N3O2S.2ClH.H2O
- Molgewicht:
- 382.31
- MOL-Datei:
- 203911-27-7.mol
|
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Eigenschaften
- Dichte
- 1.289
- RTECS-Nr.
- HM4031166
- Flammpunkt:
- 260℃
- storage temp.
- Store at -20°C
- L?slichkeit
- H2O: >10mg/mL
- Aggregatzustand
- solid
- Farbe
- white to off-white
- Wasserl?slichkeit
- Soluble in water and dimethylsulfoxide.
- InChI
- 1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
- InChIKey
- NOXXIYDYFSNHDF-UHFFFAOYSA-N
- SMILES
- Cl[H].Cl[H].O=S(=O)(N1CCCNCC1)c2cccc3cnccc23
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Rho-associated kinase (ROCK), an effector of the small GTP-binding protein Rho, plays an important role in various cellular functions including vascular smooth muscle contraction, proliferation, and migration as well as inflammatory cell mobility. HA-1077 is a potent inhibitor of ROCK2 and additionally inhibits protein kinase c-related kinase 2 (PRK2), mitogen- and stress-activated protein kinase (MSK1), and mitogen activated protein kinase-activated protein kinase 1b (MAPKAP-K
1b) with IC
50 values of 1.9, 4, 5, and 15 μM, respectively. By inhibiting the activity of ROCK, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in various rodent models. While originally marketed for the prevention of cerebral vasospasm in patients with subarachnoid hemorrhage, oral formulations of HA-1077 are used for the treatment of a wide range of cardiovascular diseases including pulmonary arterial hypertension and stable angina.
Chemische Eigenschaften
White fine crystalline powder
Verwenden
Fasudil dihydrochloride is used in the inhibition of contractile responses to potassium chloride, phenylephnne (PHE), prostaglandin and hepatic stellate cells spreading. It is also used in the formation of stress fibers and in medicine.
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 48)Lieferanten
203911-27-7()Verwandte Suche:
- 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
- HA-1077 (hydrochloride)
- 1-(5-Isoquinolinesulphonyl)homopiperazine dihydrochloride salt, Fausidil dihydrochoride salt
- HA-1077 dihydrochloride solid, >=98% (HPLC)
- Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:2)
- Fasudil 2HCl
- 203911-27-7
- Inhibitor
