Maxacalcitol
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- CAS-Nr.
- 103909-75-7
- Englisch Name:
- Maxacalcitol
- Synonyma:
- MAXACALCITOL;Macalciferol;Oxacalcitriol;D6-Maxacalcitol;Maxacalcitol, 10 mM in DMSO;Mashacalcitol/Mashacalcitol;Maxacalcitol (22-Oxacalcitriol);22-Oxa-1α,25-dihydroxycholecalciferol;(5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol;(+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol
- CBNumber:
- CB22130916
- Summenformel:
- C26H42O4
- Molgewicht:
- 418.61
- MOL-Datei:
- 103909-75-7.mol
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Maxacalcitol Eigenschaften
- Schmelzpunkt:
- 122°
- alpha
- D20 +49.4° (c = l.00 in ethanol)
- Siedepunkt:
- 581.4±50.0 °C(Predicted)
- Dichte
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- crystalline solid
- pka
- 14.43±0.40(Predicted)
- Farbe
- White to off-white
- InChIKey
- DTXXSJZBSTYZKE-ZDQKKZTESA-N
- SMILES
- [C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@@H](OCCC(O)(C)C)C)/C(=C)[C@@H](O)C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P281 |
Vorgeschriebene pers?nliche Schutzausrüstung verwenden. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Maxacalcitol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Maxacalcitol is the third synthetic vitamin D analog, after paricalcitol and
doxercalciferol, to be marketed for the treatment of secondary hyperparathyroidism (SHPT) associated with chronic renal failure. It is a new vitamin D3 derivative with an
oxygen atom in 22-position as main structural feature (22-oxacalcitriol, OCT). This vitamin
D receptor agonist has a strong inhibitory effect on synthesis and secretion of parathyroid
hormone in the setting of severe parathyroid hyperplasia. Maxacalcitol induced only minor
effects on calcium and phosphate metabolism unlike an agent such as 1, 25(OH)2D3 that
produced hypercalcemia and hyperphosphatemia. Maxacalcitol is.
Verwenden
22-Oxacalcitriol is the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.
Maxacalcitol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Maxacalcitol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 172)Lieferanten
103909-75-7()Verwandte Suche:
- MAXACALCITOL
- (5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10(19)-triene-1α,3β,25-triol
- 22-Oxa-1α,25-dihydroxycholecalciferol
- Oxacalcitriol
- (+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10(19)-triene-1,3-diol
- 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
- (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
- (1R,3S,Z)-5-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
- 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol
- (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
- Maxacalcitol (22-Oxacalcitriol)
- (1R,3S,Z)-5-((E)-2-((1S,3aS,7aS)-1-((S)-1-(3-Hydroxy-3-methylbutoxy)ethyl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
- Macalciferol
- Maxacalcitol, 10 mM in DMSO
- Mashacalcitol/Mashacalcitol
- D6-Maxacalcitol
- 103909-75-7
- 909-75-7
- API
