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Mercaptamin

Cysteamine Struktur
60-23-1
CAS-Nr.
60-23-1
Bezeichnung:
Mercaptamin
Englisch Name:
Cysteamine
Synonyma:
CYSTEAMINE;2-AMINOETHANETHIOL;mercaptamine;2-MERCAPTOETHYLAMINE;Cysteamide;Cysteamin;2-Amino-1-ethanethiol;Cisteamina;CysteaMine ~95%;2-amino-ethanethio
CBNumber:
CB2223766
Summenformel:
C2H7NS
Molgewicht:
77.15
MOL-Datei:
60-23-1.mol

Mercaptamin Eigenschaften

Schmelzpunkt:
95°C
Siedepunkt:
130 °C
Dichte
0.934 (estimate)
Brechungsindex
1.5300 (estimate)
storage temp. 
2-8°C
Wasserl?slichkeit
Soluble in water
L?slichkeit
Water (soluble), Ethanol (soluble (95% EtOH))
Aggregatzustand
Powder
pka
8.35(at 25℃)
Farbe
White to slightly yellow
Merck 
14,2779
BRN 
635649
Henry's Law Constant
2.7×101 mol/(m3Pa) at 25℃, HSDB (2015)
Stabilit?t:
Stable, but may be air-sensitive. Incompatible with strong oxidizing agents.
Kosmetik-Inhaltsstoffe Funktionen
HAIR WAVING OR STRAIGHTENING
InChI
1S/C2H7NS/c3-1-2-4/h4H,1-3H2
InChIKey
UFULAYFCSOUIOV-UHFFFAOYSA-N
SMILES
NCCS
CAS Datenbank
60-23-1(CAS DataBase Reference)
EPA chemische Informationen
Cysteamine (60-23-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36/37/38
S-S?tze: 26-36
RIDADR  3259
WGK Germany  3
RTECS-Nr. KJ0175000
1-3-10-13-34
HS Code  29309090
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Giftige Stoffe Daten 60-23-1(Hazardous Substances Data)
Toxizit?t LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Mercaptamin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Cysteamine, also known as 2-aminoethanethiol, is a chemical compound with the formula HSCH?CH?NH?. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH2CH2NH3Cl. The comparatively high melting point of cysteamine (95-97 °C), indicates that exists in a salt form.

Chemische Eigenschaften

2-Aminoethanethiol is a white to pale yellow solid powder with a melting point of 99–100°C. It is readily soluble in water and alcohols, exhibits an alkaline reaction, and readily oxidises to form disulphides in air. The free base is highly unstable and is generally formulated as the hydrochloride salt [156-57-0].
Cysteamine or 2-Aminoethanethiol

Definition

2-AMINOETHANETHIOL is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2. It is an antihyperlipidemic and HMG-CoA reductase inhibitor.

synthetische

Cysteamine can also be prepared by the reaction of ethylenimine with hydrogen sulfide.
(NHCH2CH2) + H2S → HSCH2CH2NH2.

Reaktionen

2-AMINOETHANETHIOL is used as the hydrochloride salt, as it readily oxidizes to the corresponding disulfide, in the presence of air. The amine portion of the molecule serves as a catalyst for this reaction.
4 HSCH2CH2NH2 + O2 → 2 NH2CH2CH2SSCH2CH2NH2 + 2 H2O.

Pharmazeutische Anwendungen

Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria.
It is also used for treatment of radiation sickness.
Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate.
In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis.

Sicherheitsprofil

Poison by intravenous, subcutaneous, and intraperitoneal routesModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NOx,.

l?uterung methode

It is soluble in H2O giving an alkaline reaction, and it has a disagreeable odour. A likely impurity is the disulfide cystamine which is not soluble in alkaline solution. Under a N2 atmosphere dissolve it in EtOH, evaporate to dryness and wash the white residue with dry pet ether, then sublime it at 0.1mm and store it under N2 at 0-10o in the dark. Its HgCl2 (2:3) complex has m 181-182o (from H2O), and its picrate has m 125-126o. [Mills & Bogert J Am Chem Soc 57 2328 1935, 62 1173 1940, Baddiley & Thain J Chem Soc 800 1952, Shirley Preparation of Organic Intermediates (J. Wiley) Vol 3 189 1951, Barkowski & Hedberg J Am Chem Soc 109 6989 1987, Beilstein 4 IV 1570.]

Mercaptamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Mercaptamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 362)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Zhuanglai Chemical Trading Co Ltd
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
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18853181302
sale@chuangyingchem.com CHINA 5906 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15003564040
1056@dideu.com China 3971 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 9542 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10236 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58

60-23-1(Mercaptamin)Verwandte Suche:


  • 2-Aminoethyl mercaptan
  • 2-aminoethylmercaptan
  • THIOETHANOLAMINE
  • 2-MERCAPTOETHYLAMINE, POLYMER-BOUND
  • DECARBOXYCYSTEINE
  • AURORA KA-7615
  • Beeaptan
  • BETA-MERCAPTOETHYLAMINE
  • 2-Aminoet-hylmercaptan
  • 2-Mercaptoethanamine
  • Ethanethiol, 2-aMino-(8CI,9CI)
  • Cysteamine(β-MEA)
  • Aminoethyl mercaptan
  • Becaptan
  • beta-Aminoethanethiol
  • beta-Aminoethylthiol
  • beta-MEA
  • Cysteinamine
  • Ethanethiol, 2-amino-
  • Ethanethiolamine
  • L-1573
  • Lambraten
  • Lambratene
  • Mecramine
  • Mercamin
  • Mercamine
  • Mercaptamin
  • -Mercaptoethylamine
  • Merkamin
  • Riacon
  • 2-Aminoethanthiol
  • 2-mercaptoethylamine free base
  • 2,2,4-trimethyl-1,2-dihydroquinoline (oligomers)
  • C01678
  • Cysteamine,β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine
  • Cysteamine 2-Mercaptoethylamine
  • CYSTEAMINE HYDROCHLORIDE(P)
  • β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine
  • cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine
  • 2-mercaptoethylammonium
  • JACS-60-23-1
  • 2-Aminoethanethiol >
  • Aminoethanethiol...
  • cysteanine
  • 2-AMINOETHANETHIOL USP/EP/BP
  • β-MEA
  • 2-Aminoethanethiol (Cysteamine)
  • 2-amino-ethanethio
  • CYSTEAMINE
  • Cysteamin
  • mercaptamine
  • Cisteamina
  • Cysteamine (β-Mercaptoethylamine)
  • 2-Aminpoethanethiol
  • (2-Mercaptoethyl)amine (Mercaptoethyl)ammonium toluene-p-sulphonate 1-Amino-2-mercaptoethylamine 2-AMINO-ETHANETHIOL 2-Amino-1-ethanethiol 2-Aminoethanethiol 2-Aminoethyl mercaptan 2-Mercaptoet
  • Cysteamine Powder
  • 75%Cysteamine
  • 95%Cysteamine
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