HUMAN PAI-1
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- CAS-Nr.
- 140208-23-7
- Englisch Name:
- HUMAN PAI-1
- Synonyma:
- PAIE;PLANH1;Serpine 1;HUMAN PAI-1;PAI-1, MUTANT;Serpin E1 PAI-1;PAI-1, MUTANT, HUMAN;Human SERPINE1 Protein, His Tag;HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-1;Recombinant Mouse Serpine1 Protein, His Tag
- CBNumber:
- CB2231028
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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HUMAN PAI-1 Eigenschaften
- storage temp.
- -20°C
- L?slichkeit
- water: 0.1 mL, clear, colorless
- Aggregatzustand
- lyophilized powder
- Wasserl?slichkeit
- water: 0.1mL, clear, colorless
- Specific Activity
- ≥200,000units/mg protein
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
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| HS Code |
3504009000 |
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| Speicherklasse |
10 - Combustible liquids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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HUMAN PAI-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Plasminogen activator inhibitor 1 (PAI-1) human has been used:
- as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes
- to block plasmin activation in mice infected with C. albicans hyphae
- to test its effect on neurite growth in neurons
Allgemeine Beschreibung
Plasminogen activator inhibitor 1 (PAI-1) or serine protease inhibitor E1 (SERPINE1) gene is mapped to human chromosome 7q22.1. PAI-1 is produced in hepatocytes, endothelial cells, smooth muscle cells, megakaryocytes, and adipocytes.
Biochem/physiol Actions
Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome.
HUMAN PAI-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
HUMAN PAI-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 51)Lieferanten
- PLASMINOGEN ACTIVATOR INHIBITOR-1, MUTANT, HUMAN
- PLASMINOGEN ACTIVATOR INHIBITOR-1, MUTANT, HUMAN, RECOMBINANT
- PAI-1, MUTANT
- PAI-1, MUTANT, HUMAN
- HUMAN PAI-1
- HUMAN PLASMINOGEN ACTIVATOR INHIBITOR-1
- PAIE
- PLANH1
- Plasminogen activator inhibitor 1 (PAI-1) human
- Plasminogen activator inhibitor, β-migrating endothelial cell-derived type
- Serpin E1 PAI-1
- Serpine 1
- Plasminogen activator inhibitor 1 (PAI-1) human recombinant, expressed in E. coli, >=90% (SDS-PAGE)
- Recombinant Human SSERPINE1 Protein, His Tag
- Recombinant Mouse Serpine1 Protein, His Tag
- Human SERPINE1 Protein, His Tag
- 140208-23-7
