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Romiplostim

Romiplostim Struktur
267639-76-9
CAS-Nr.
267639-76-9
Englisch Name:
Romiplostim
Synonyma:
Romiplostim;romiplostim(Nplate)
CBNumber:
CB22502861
Summenformel:
C15H14N2O
Molgewicht:
238.28446
MOL-Datei:
267639-76-9.mol

Romiplostim Eigenschaften

InChI
InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-
InChIKey
WUWDLXZGHZSWQZ-WQLSENKSSA-N
SMILES
N1C2=C(C=CC=C2)/C(=C/C2=C(C)C=C(C)N2)/C1=O

Sicherheit

Romiplostim Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Romiplostim has been developed and launched for the treatment of thrombocytopenia in patients with ITP, an autoimmune blood disorder in which there is autoantibody-mediated platelet destruction. Coating of the platelets by autoantibodies results in accelerated ingestion by macrophages. In addition to the destruction component, ITP is also characterized by impaired platelet production. The primary physiological regulator of platelet production is thrombopoietin (TPO), a growth factor that orchestrates its effects through the TPO (Mpl) receptor.Agonists of this receptor could, thereby, remediate the platelet production contribution of ITP. By binding to and activating the TPO receptor, romiplostim serves as a TPO receptor agonist. As a recombinant fusion protein, in this case coined as a peptibody, it was engineered to contain two identical single-chain subunits, each consisting of a TPO-binding domain linked to the C-terminus of a human IgG1 Fc domain designed to increase the half-life of the protein. Although it binds to the TPO receptor, romiplostim has no sequence homology to endogenous TPO, which should mitigate the risks encountered with the first generation predecessor, recombinant megakaryocyte growth and development factor (MGDF); this truncated, non-glycosylated form of TPO conjugated to PEG was halted during clinical studies because of the immunogenicity of PEG-MGDF resulting in cross-reacting (neutralizing) antibodies against endogenous TPO and subsequent severe, unrelenting thrombocytopenia. Romiplostim also avoids the side effects associated with the generalized immunosuppressive agents previously employed for the treatment of ITP and may prevent splenectomy, another common treatment option.

Originator

Amgen (United States)

Trademarks

Nplate

Mechanism of action

Romiplostim is a thrombopoietin receptor agonist (TPO-RA) that increases platelet production by activating intracellular transcriptional pathways through c-Mpl. It also acts similarly to thrombopoietin (TPO), an endogenous glycoprotein hormone that regulates platelet production in the bone marrow. Romiplostim is a peptibody that contains four TPO-R binding domains with high affinity for TPO-R (MPL), and a carrier Fc domain with no sequence homology to endogenous TPO. Romiplostim binds to and activates TPO-R on megakaryocyte precursors in the bone marrow in the same manner as endogenous TPO and can displace TPO on its receptor. It may also be able to activate Tregs through two epitopes in the Fc region, called Tregitopes, which in turn promote cell viability, cell growth, intramegakaryocyte mitosis, megakaryocyte maturation, and importantly, platelet production.

Romiplostim Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Romiplostim Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 22)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BJV BIOTECH LTD
+86-0755-23089946 +8619006605307
bjvbiotech@163.com China 67 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21586 55
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
Win-Win chemical CO., Limited
+86-0086-577-64498589 +86-15355981851
sales@win-winchemical.com China 14304 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471;
sales@sarms4muscle.com China 10473 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 861 58
BJV(SHENZHEN) BIOTECH LTD 0755-23089946 19006605307
1026972457@qq.com China 96 58
Chembest Research Laboratories Limited 021-20908456
sales@BioChemBest.com China 6002 61
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
China 1493 55

  • Romiplostim
  • romiplostim(Nplate)
  • 267639-76-9
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