Febuxostat-d9 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Febuxostat-d₉ is intended for use as an internal standard for the quantification of febuxostat by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC₅₀s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the hypoxanthine analog allopurinol (; K_is = 0.7 nM and 0.7 μM, respectively). Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED₅₀ = 1.5 mg/kg). It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day. Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE). Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.

Verwenden

Febuxostat-d9 is a Labeled compound, intended for use as an internal standard for the quantification of Febuxostat by GC- or LC-mass spectrometry.

Febuxostat-d9 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Febuxostat-d9 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39037	58
Artis Biotech Co. Ltd.	19138486554 18108108965	sales@artisbio.com	China	2404	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
Bide Pharmatech Ltd.	400-400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Quality Control Solutions Ltd.	0755-66853366 13670046396	orders@qcsrm.com	China	18190	56
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
Guangzhou QiYun Biotechnology Co., Ltd.	020-61288194 61288195	505721671@qq.com	China	3866	58
Clearsynth Canada Inc.	+1.415.685.4395	enquiry@clearsynth.com	Canada	912	58

1246819-50-0()Verwandte Suche:

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• Febuxostat-d9
• 2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid
• 2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
• TEI 6720-d9
• TMX 67-d9
• [2H9]-Febuxostat
• Febuxostat-d9 (2-methylpropoxy-d9)
• Febuxostat D9Q: What is Febuxostat D9 Q: What is the CAS Number of Febuxostat D9 Q: What is the storage condition of Febuxostat D9 Q: What are the applications of Febuxostat D9
• Febuxostat-d
• 2-(3-Cyano-4-(2-(methyl-d3)propoxy-1,1,2,3,3,3-d6)phenyl)-4-methylthiazole-5-carboxylic acid
• 5-Thiazolecarboxylic acid, 2-[3-cyano-4-[2-(methyl-d3)propoxy-1,1,2,3,3,3-d6]phenyl]-4-methyl-
• Dapagliflozin Impurity 138
• D9-Febuxostat
• 1246819-50-0
• C16H7D9N2O3S
• Inhibitors
• Intermediates & Fine Chemicals
• Isotope Labelled Compounds
• Pharmaceuticals
• Heterocycles