5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS-Nr.
1134156-31-2
Englisch Name:
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Synonyma:
CS-1647;VER 155088;VER 155008;HSP70 inhibitor;VER155008 ,S7751;VER-155008, ≥98% (HPLC);VER-155008, 10 mM in DMSO;VER 155008;VER-155008;VER155008;8-(3,4-Dichlorobenzyl)aMino-5'-O-(4-cyanobenzyl)adenosine;8-(3,4-Dichlorobenzyl)amino-5’-O-(4-cyanobenzyl)adenosine, VER155008
CBNumber:
CB22518790
Summenformel:
C25H23Cl2N7O4
Molgewicht:
556.4
MOL-Datei:
1134156-31-2.mol
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Eigenschaften
Siedepunkt:
856.3±75.0 °C(Predicted)
Dichte
1.63±0.1 g/cm3(Predicted)
storage temp.
2-8°C
L?slichkeit
DMSO: >10mg/mL
pka
13.04±0.70(Predicted)
Aggregatzustand
powder
Farbe
white to light brown
InChIKey
ZXGGCBQORXDVTE-UMCMBGNQSA-N
SMILES
O(CC1=CC=C(C#N)C=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2NCC2=CC=C(Cl)C(Cl)=C2)[C@H](O)[C@@H]1O
Sicherheit
WGK Germany
3
Speicherklasse
11 - Combustible Solids
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
VER 155008 is a novel adenosine-derived inhibitor of heat-shocked protein 70, Hsp70 resulting in an inhibition of cell proliferation of human cancer cell lines.
Biochem/physiol Actions
VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 138)Lieferanten
China 115
India 2
The Netherlands 1
United Kingdom 1
United States 19
Global 138
VER 155008
4-((((2R,3S,4R,5R)-5-(6-aMino-8-((3,4-dichlorobenzyl)aMino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)benzonitrile
8-(3,4-Dichlorobenzyl)aMino-5'-O-(4-cyanobenzyl)adenosine
4-{(2R,3S,4R,5R)-5-[6-aMino-8-(3,4-dichlorobenzylaMino)purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-ylMethoxyMethyl}benzonitrile
VER 155088
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
VER-155008, ≥98% (HPLC)
8-(3,4-Dichlorobenzyl)amino-5’-O-(4-cyanobenzyl)adenosine, VER155008
Adenosine, 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-
HSP70 inhibitor
VER 155008;VER-155008;VER155008
CS-1647
VER-155008, 10 mM in DMSO
VER155008 ,S7751
1134156-31-2
C25H23Cl2N7O4