MK8245
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- CAS-Nr.
- 1030612-90-8
- Englisch Name:
- MK8245
- Synonyma:
- CS-1662;]-5-isoxazoL;]-2H-tetrazoL;MK 8245;MK8245;e-2-acetic acid;MK8245 USP/EP/BP;5-[3-[4-(2-Bromo-5-fL;MK8245;MK-8245;MK 8245;MK-8245, 10 mM in DMSO;uorophenoxy)-1-piperidinyL
- CBNumber:
- CB22546432
- Summenformel:
- C17H16BrFN6O4
- Molgewicht:
- 467.25
- MOL-Datei:
- 1030612-90-8.mol
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MK8245 Eigenschaften
- Siedepunkt:
- 698.3±65.0 °C(Predicted)
- Dichte
- 1.82
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- ≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- Aggregatzustand
- solid
- pka
- 2.85±0.10(Predicted)
- Farbe
- White to off-white
- InChI
- 1S/C17H16BrFN6O4/c18-12-2-1-10(19)7-13(12)28-11-3-5-24(6-4-11)15-8-14(29-22-15)17-20-23-25(21-17)9-16(26)27/h1-2,7-8,11H,3-6,9H2,(H,26,27)
- InChIKey
- UJEAABFSXKCSGI-UHFFFAOYSA-N
- SMILES
- Fc1cc(c(cc1)Br)OC2CCN(CC2)c3n[o]c(c3)c4n[n](nn4)CC(=O)O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
5.2 - Organic peroxides and self-reacting hazardous materials |
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| Hazard Classifications |
Self-react. C |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H242 |
Erw?rmung kann Brand verursachen. |
Organische Peroxide |
Typen C & D |
Achtung
Warnung |
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P210, P220, P234, P280, P370+P378,P403+P235, P411, P420, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P234 |
Nur im Originalbeh?lter aufbewahren. |
| P235 |
Kühl halten |
| P240 |
Beh?lter und zu befüllende Anlage erden. |
| P370+P378 |
Bei Brand: zum L?schen verwenden. |
| P403 |
An einem gut belüfteten Ort aufbewahren. |
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MK8245 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC
50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ
5- and Δ
6-desaturases (IC
50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC
50 = 39.8 nM).
Verwenden
This product is Informer compound X9 of the
Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.
MK8245 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
MK8245 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 100)Lieferanten
- 5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
- 2-(5-(3-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid
- MK 8245;MK8245
- MK8245;MK-8245;MK 8245
- CS-1662
- ]-2H-tetrazoL
- ]-5-isoxazoL
- 5-[3-[4-(2-Bromo-5-fL
- e-2-acetic acid
- uorophenoxy)-1-piperidinyL
- 2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-
- MK8245 USP/EP/BP
- 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]aceticaci
- MK-8245, 10 mM in DMSO
- 2-(5-(3-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid
- 1030612-90-8
- C17H16BrFN6O4
- Inhibitors
- Inhibitor
