N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
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- CAS-Nr.
- 1190378-57-4
- Englisch Name:
- N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
- Synonyma:
- MRT68921;MRT67307 hydrochloride;CS-2840;MRT67307;MRT67307 HCl;MRT67307 (MRT 67307;MRT67307 (free base);MRT67307, 10 mM in DMSO;MRT67307 HCl(free-base);IKKε/TBK1 Inhibitor II, MRT67307
- CBNumber:
- CB22547040
- Summenformel:
- C26H36N6O2
- Molgewicht:
- 464.6
- MOL-Datei:
- 1190378-57-4.mol
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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Eigenschaften
- Dichte
- 1.270
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- L?slichkeit
- H2O: soluble15mg/mL, clear
- Aggregatzustand
- powder
- pka
- 15.94±0.20(Predicted)
- Farbe
- white to light brown
- Wasserl?slichkeit
- H2O: 15mg/mL, clear
- InChIKey
- UKBGBACORPRCGG-UHFFFAOYSA-N
- SMILES
- C1(C(NCCCNC2C(C3CC3)=CN=C(NC3=CC=CC(CN4CCOCC4)=C3)N=2)=O)CCC1
Sicherheit
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation.
Biochem/physiol Actions
MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation.
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 119)Lieferanten
- MRT67307
- N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide hydrochloride
- N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
- MRT67307 (free base)
- IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem
- MRT67307 HCl
- CS-2840
- Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
- MRT67307 HCl(free-base)
- MRT67307, 10 mM in DMSO
- IKKε/TBK1 Inhibitor II, MRT67307
- MRT67307 (MRT 67307
- MRT68921
- MRT67307 hydrochloride
- 1190378-57-4
- C26H36N6O2xHCl
- NF-kB
- API
