Histone Acetyltransferase Inhibitor IV, CPTH2

357649-93-5

CAS-Nr.: 357649-93-5

Englisch Name:: Histone Acetyltransferase Inhibitor IV, CPTH2

Synonyma:: CPTH2;CPTH2 ，S1242;CPTH2, 10 mM in DMSO;Histone Acetyltransferase Inhibitor IV, CPTH2;Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone;Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole;4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole , CPTH2

CBNumber:: CB22602855

Summenformel:: C14H14ClN3S

Molgewicht:: 291.8

MOL-Datei:: 357649-93-5.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 101

Histone Acetyltransferase Inhibitor IV, CPTH2 Eigenschaften

Schmelzpunkt:: 190-191 °C

Siedepunkt:: 460.3±37.0 °C(Predicted)

Dichte: 1.38±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

L?slichkeit: Soluble in DMSO

Aggregatzustand: powder

pka: 14.57±0.20(Predicted)

Farbe: white to beige

Wasserl?slichkeit: Water: < 0.1 mg/mL (insoluble)

Sensitive: Light Sensitive

Stabilit?t:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

InChI: InChI=1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)

InChIKey: YYTHPXHGWSAKIZ-UHFFFAOYSA-N

SMILES: C1(=N/NC2=NC(C3=CC=C(Cl)C=C3)=CS2)/CCCC/1

Sicherheit

WGK Germany	nwg
Speicherklasse	11 - Combustible Solids

Histone Acetyltransferase Inhibitor IV, CPTH2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo.

Allgemeine Beschreibung

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.

Biochem/physiol Actions

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Histone Acetyltransferase Inhibitor IV, CPTH2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1-Cyclopentylidenethiosemicarbazide Brommethyl-p-chlorphenylketon Cyclopentanon

Downstream Produkte

Histone Acetyltransferase Inhibitor IV, CPTH2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 101)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9947	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	18130062233	690231469@qq.com	China	8100	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

357649-93-5()Verwandte Suche:

Daminozid

Histone Acetyltransferase Inhibitor IV, CPTH2
CPTH2
Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone
4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole
4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole
4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazineyl)thiazole , CPTH2
CPTH2, 10 mM in DMSO
CPTH2 ，S1242
357649-93-5
HAT Inhibitor IV, Gcn5p Inhibitor, CPTH2
Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals

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