LMK-235
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- CAS-Nr.
- 1418033-25-6
- Englisch Name:
- LMK-235
- Synonyma:
- CS-1820;LMK-235;LMK235; LMK 235;LMK-235, 10 mM in DMSO;LMK 235, HDAC inhibitor;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide;Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
- CBNumber:
- CB22655624
- Summenformel:
- C15H22N2O4
- Molgewicht:
- 294.35
- MOL-Datei:
- 1418033-25-6.mol
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LMK-235 Eigenschaften
- Schmelzpunkt:
- 135-138°C
- Dichte
- 1.155±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble20mg/mL, clear
- Aggregatzustand
- powder
- pka
- 9.46±0.20(Predicted)
- Farbe
- white to beige
- InChI
- 1S/C15H22N2O4/c1-11-8-12(2)10-13(9-11)15(19)17-21-7-5-3-4-6-14(18)16-20/h8-10,20H,3-7H2,1-2H3,(H,16,18)(H,17,19)
- InChIKey
- VRYZCEONIWEUAV-UHFFFAOYSA-N
- SMILES
- N(OCCCCCC(=O)NO)C(=O)c1cc(cc(c1)C)C
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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LMK-235 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, which commonly results in chromatin condensation and transcriptional repression. LMK 235 is an HDAC inhibitor that selectively targets HDACs 4 and 5 (IC
50s = 12 and 4 nM, respectively) over other HDACs (IC
50s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively). It displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA or trichostatin A . LMK 235 and derivatives inhibit the growth of the malarial parasite
P. falciparum at multiple life cycle stages at nanomolar concentrations.
Verwenden
LMK 235 is a histone deacetylase (HDAC)4 and HDAC5 inhibitor and has shown to have enhanced cytotoxic effects against the human cancer cell lines A2780, Cal27, Kyse510, and MDA-MB231.
Biochem/physiol Actions
LMK-235 induces the differentiation of odontoblasts in dental pulp cells. It plays an important role in the regeneration of dental tissue.
LMK-235 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LMK-235 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 131)Lieferanten
- N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide
- N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
- LMK-235
- CS-1820
- LMK235; LMK 235
- Benzamide, N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-
- LMK 235, HDAC inhibitor
- LMK-235, 10 mM in DMSO
- 1418033-25-6
- 1418033-85-6
- Inhibitors
