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AC-262536

AC-262536 Struktur
870888-46-3
CAS-Nr.
870888-46-3
Englisch Name:
AC-262536
Synonyma:
AC262;AC-262,356;ACP-262;Accadine;AC-262536;AC-262536;AC262;AC-262536 powder;AC-262536, 10 mM in DMSO;9-[1,1'-biphenyl]-4-yl-9H-Carbazol-3-amine;4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-
CBNumber:
CB22750956
Summenformel:
C18H18N2O
Molgewicht:
278.36
MOL-Datei:
870888-46-3.mol

AC-262536 Eigenschaften

Schmelzpunkt:
158-162°C
Siedepunkt:
526.0±45.0 °C(Predicted)
Dichte
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: Soluble
pka
14.73±0.20(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
Major Application
forensics and toxicology
pharmaceutical (small molecule)
InChI
InChI=1/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15+
InChIKey
ATKWLNSCJYLXPF-FICVDOATNA-N
SMILES
O[C@H]1C[C@H]2CC[C@H](N2C2=CC=C(C#N)C3C=CC=CC2=3)C1 |&1:1,3,6,r|

Sicherheit

WGK Germany  3
Speicherklasse 11 - Combustible Solids

AC-262536 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

AC-262536 is a hydrocarbon organic matter and can be used as pharmaceutical intermediates.

Allgemeine Beschreibung

AC-262536 is a selective nonsteroidal androgen receptor modulator (SARM) with beneficial anabolic effects. AC-262536 has potent agonist activity against androgen receptors with affinity in the low nanomolar range (1-10 nM). It is another novel drug put forth by Acadia, just like ACP-105. It is a SARM by design, as it selectively binds to the androgen receptor, just like all the other SARMs. AC-262536 came into light in 2007 and even though 13 years have passed, little research has been done on this compound.

Biologische Aktivit?t

AC-262536 exhibits potency at AR similar to that observed for the natural ligand testosterone, 13 nM vs. 2 nM, respectively. Interestingly, AC-262536 behaved as a partial agonist (% Eff 67 ± 9) relative to testosterone. In reporter gene assays, AC-262536 modulated the transcriptional activity of a natural target gene in an AR-dependent manner with low nanomolar potency (2 nM). It displayed partial agonism properties (% Eff 72 ± 9) relative to testosterone. Further, AC-262536 physically interacted with AR with an affinity of 5 nM. Profiling at other nuclear receptors revealed that AC-262536 is extremely selective for AR, having no significant affinity for the other 47 human nuclear receptors, including the steroid receptors estrogen ERs, glucocorticoid GR, mineraloid MR, and progesterone PR, at doses as high as 10M (data not shown)[1].

Nebenwirkungen

Testosterone Suppression: AC-262536 will suppress your natural testosterone levels. Compared to other SARMs, this suppression of testosterone is rather mild and similar to that of Ostarine and Andarine. Testosterone suppression can manifest in the following symptoms: Lethargy, Lack of motivation, Decreased libido, Weaker erections, Testicular pain, and Testicular atrophy. AC-262536 will cause dyslipidemia. Your HDL will decrease, and your LDL will increase during an AC-262 cycle. The extent of this side effect can be compared to that of similarly strong SARMs. The following side effects can happen to anyone who alters their endocrine balance, regardless of whether they’re taking AC-262 or something else: Gynecomastia: men who had pubertal gyno are at risk of redeveloping it if they take AC-262536; Hair shedding (temporary and completely reversible); Insomnia.

AC-262536 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AC-262536 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 94)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Demeikai Biotechnology Co., Ltd
+8618942921723
info@dmksw.xin China 717 58
Hebei Xinsheng New Material Technology Co., LTD.
+86-16632316109
xinshengkeji@xsmaterial.com China 1085 58
Shanghai Longyu Biotechnology Co., Ltd.

info@longyupharma.com China 2423 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533
Brad@rongnabiotech.com China 3376 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039
admin@firsky-cn.com China 427 58
qingdao future trading Co., Ltd
+86-13335044410
cui56813@163.com China 110 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580
da@zhongda-biotech.com China 232 58
Anhui Zhongda Biotechnology Co., Ltd
+8615689548120
linda@zhongda-biotech.com China 193 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58

  • AC-262536
  • 4-(3-endo-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
  • 4-[(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl]naphthalene-1-carbonitrile
  • AC-262536;AC262
  • AC-262536 powder
  • 4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
  • 1-Naphthalenecarbonitrile, 4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-
  • 1-Naphthalenecarbonitrile,4-[(3-endo)-3-hydroxy-8-azabicyclo...
  • Accadine
  • AC-262,356
  • 4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-
  • ACP-262
  • SARM,modulator,AC-262536,Inhibitor,AC 262536,receptor,androgen,anabolic,Androgen Receptor,inhibit,non-steroidal
  • 4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-naphthalenecarbonitrile
  • 9-[1,1'-biphenyl]-4-yl-9H-Carbazol-3-amine
  • AC-262536, 10 mM in DMSO
  • 4-[(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl]naphthalene-1-carbonitrile
  • 4- (3-endo-hydroxy-8-azabicyclo [3.2.1] octan-8-yl) naphthalene-1-carbonitrile
  • AC262
  • 870888-46-3
  • 870888-46-3
  • SARMS
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