5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid
|
|
|
- CAS-Nr.
- 636-00-0
- Bezeichnung:
- 5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid
- Englisch Name:
- 6-HYDROXYDOPAMINE HYDROBROMIDE
- Synonyma:
- 6-HYDROXYDOPAMINE HBR;6-OHDA (Oxidopamine hydrobromide);Oxidopamine HBr;6-OHDA (hydrobromide);6-Hydroxydopamine hydrbromide;2,4,5-Trihydroxyphenethylamine;6-HYDROXYDOPAMINE HYDROBROMIDE;KEMPTIDE, SYNTHETIC, >97% PURITY;Oxidopamine (6-OHDA) hydrobromide;6-HYDROXYDOPAMINE HYDROBROMIDE 99%
- CBNumber:
- CB2288961
- Summenformel:
- C8H12BrNO3
- Molgewicht:
- 250.09
- MOL-Datei:
- 636-00-0.mol
|
5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid Eigenschaften
- Schmelzpunkt:
- 216-220 °C(lit.)
- storage temp.
- -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- solid
- Farbe
- tan to brown
- BRN
- 3713280
- Stabilit?t:
- Hygroscopic, Light Sensitive
- InChI
- InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
- InChIKey
- MLACDGUOKDOLGC-UHFFFAOYSA-N
- SMILES
- C(C1C=C(O)C(O)=CC=1O)CN.Br
- CAS Datenbank
- 636-00-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
|
|
| R-S?tze: |
36/37/38 |
|
|
| S-S?tze: |
26-36 |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
DC4600000 |
|
|
| F |
3-10 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
|
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.
Chemische Eigenschaften
beige to brown crystalline powder
Verwenden
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
Allgemeine Beschreibung
Solutions should be freshly prepared and protected from exposure to light.
5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 199)Lieferanten
636-00-0(5-(2-Aminoethyl)-4-hydroxypyrocatechinhydrobromid)Verwandte Suche:
- 1,2,4-Benzenetriol,5-(2-aminoethyl)-, hydrobromide (1:1)
- 2,4-benzenetriol,5-(2-aminoethyl)-hydrobromide
- 2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROBROMIDE
- 2,5-DIHYDROXYTYRAMINE HYDROBROMIDE
- 2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROBROMIDE
- 6-HYDROXYDOPAMINE HYDROBROMIDE
- 2,4,5-Trihydroxyphenethylamine
- 5-(2-aminoethyl)-4-hydroxypyrocatechol hydrobromide
- 6-Hydroxydopamine hydrbromide
- 6-HYDROXYDOPAMINE HYDROBROMIDE WITH ASCO RBIC ACID
- 6-HYDROXYDOPAMINE HYDROBROMIDE 99%
- 2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
- 6-Hydroxydopamine·hydrogen bromide
- 6-Hydroxydopamine hydrobromide,95%
- 6-Hydroxydopamine hydrobromide,99%
- 2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide
- 6-HYDROXYDOPAMINE HYDROBROMIDE, CRYSTALL IZED
- 6-Hydroxydopamine hydrobromide,2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
- KEMPTIDE, SYNTHETIC, >97% PURITY
- 6-Hydroxydopaminehydrobromide/ascorbicacid
- 5-(2-aMinoethyl)benzene-1,2,4-triol hydrobroMide
- Oxidopamine HBr
- 6-Hydroxydopamine hydrobromide contains ascorbic acid as stabilizer, >=98% (HPLC)
- 6-OHDA (hydrobromide)
- 6-HYDROXYDOPAMINE HYDROBROMIDE USP/EP/BP
- 6-OHDA HBr (Oxidopamine hydrobromide)
- neurotoxicity,Autophagy,Interleukin Related,Parkinson’s disease,6-Hydroxydopamine,Oxidopamine hydrobromide,Caspase,6-OHDA,Lesch-Nyhan syndrome,PC12 cells,p38 MAPK,Mitophagy,inhibit,Inhibitor,Mitochondrial Autophagy,p-p38,COX,Prostaglandin E synthase,attention-deficit hyperactivity disorder,PGE2,Dopamine Receptor,SH-SY5Y cells,Apoptosis,Oxidopamine,Neuro-2a cells,Cyclooxygenase,PGE synthase
- Oxidopamine (6-OHDA) hydrobromide
- Oxidopamine hydrobromide, 10 mM in DMSO
- 6-Hydroxydopamine hydrobromide【162957】
- 5-(2-Aminoethyl)-benzene-1,2,4-triol HBr
- 6-HYDROXYDOPAMINE HBR
- 6-OHDA (Oxidopamine hydrobromide)
- 636-00-0
- HO3C6H2CH2CH2NH2HBr
- C8H11N1O3
- C8H12NO3Br
- C8H11NO3HBr
- C8H11NO3BrH
- Organic Building Blocks
- Oxygen Compounds
- Building Blocks
- Amino Alcohols
- Dopamine receptor
- Amino Alcohols
- Bioactive Small Molecules
- Building Blocks
- Cell Biology
- Chemical Synthesis
- H
- Organic Building Blocks
- Oxygen Compounds
