FRAX1036

1432908-05-8

CAS-Nr.: 1432908-05-8

Englisch Name:: FRAX1036

Synonyma:: CS-2271;FRAX1036;FRAX-1036;FRAX 1036;FRAX1036 (Free base);FRAX1036, 10 mM in DMSO;FRAX 1036,Inhibitor,p21 activated kinases,PAK,FRAX1036,inhibit,FRAX-1036;6-(2-Chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-

CBNumber:: CB23122927

Summenformel:: C28H32ClN7O

Molgewicht:: 518.05

MOL-Datei:: 1432908-05-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 71

FRAX1036 Eigenschaften

Siedepunkt:: 669.8±65.0 °C(Predicted)

Dichte: 1+-.0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

L?slichkeit: Soluble in DMSO

Aggregatzustand: crystalline solid

pka: 9.46±0.10(Predicted)

Farbe: White to light yellow

InChIKey: RYCBSFIKWACFBY-UHFFFAOYSA-N

SMILES: Clc1c(ccc(c1)c5nc(cnc5)C)c2[c]([n](c3nc(ncc3c2)NCCC4CCN(CC4)C)CC)=O

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

FRAX1036 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel . Disruption of PAK1 via FRAX1036 has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells.

FRAX1036 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2-(1-Methylpiperidin-4-yl)ethanamine Methyl 2-(4-broMo-2-chlorophenyl)acetate

Downstream Produkte

FRAX1036 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 71)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49709	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Aladdin Scientific		tp@aladdinsci.com	United States	57473	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4860	55

FRAX1036
FRAX1036 (Free base)
FRAX-1036;FRAX 1036
CS-2271
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-
6-(2-Chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
FRAX 1036,Inhibitor,p21 activated kinases,PAK,FRAX1036,inhibit,FRAX-1036
6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one
FRAX1036, 10 mM in DMSO
1432908-05-8
C28H32ClN7O

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