ALAMETHICIN
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- CAS-Nr.
- 59588-86-2
- Englisch Name:
- ALAMETHICIN
- Synonyma:
- f-50;U-22324;ALMETHICIN;ALAMETHICIN;ALAMETHACIN;alamethicini;alamethicinf30;alamethicingamma;ANTIBIOTIC U-22324
- CBNumber:
- CB2423618
- Summenformel:
- C92H150N22O25
- Molgewicht:
- 1964.31
- MOL-Datei:
- 59588-86-2.mol
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ALAMETHICIN Eigenschaften
- Schmelzpunkt:
- 267-270℃
- RTECS-Nr.
- AY1900000
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO and ethanol.
- Aggregatzustand
- Powder
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 3462 6.1/PG 3 |
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| WGK Germany |
3 |
|
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| F |
10-21 |
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| HazardClass |
6.1 |
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| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P321 |
Besondere Behandlung |
| P405 |
Unter Verschluss aufbewahren. |
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ALAMETHICIN Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Verwenden
Alamethicin is used as a channel-forming ionophore that activates membrane enzymes, membrane channel-forming peptide. It is a 20-amino acid channel-forming peptide antibiotic that can function as a monovalent cation ionophore. Alamethicin has been used to develop methods for the routine assessment of potential new drug candidates to elicit their pharmacokinetic drug interactions.
Enzyminhibitor
These voltage-dependent, channel-forming, peptaibol antibiotics
(MWAlamethicin F-30 = 1964.40; CAS 27061-78-5) from the soil fungus
Trichoderma viride NRRL 3199 are membrane-active oligopeptides
isolated from that exhibit anti-bacterial and anti-fungal properties.
Peptaibols are amphipathic, usually highly helical in structure, and
typically form voltage dependent ion channels that uncouple oxidative
phosphorylation, often attended by in bacterial and fungal cell death.
Alamethicin F-30 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-
Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phe-OH; Alamethicin F-
50 has the sequence Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-
Leu-Aib-Pro-Val-Aib Aib-Gln-Gln-Phe-OH; and Alamethicin II has the
sequence Ac-Aib-Pro-Aib-Ala-Aib-Aib-Gln-Aib-Val-Aib-Gly-Leu-Aib-
Pro-Val-Aib-Aib-Glu-Gln-Phe-OH. Note: The name “peptaibol” is derived
from the prefix “pep-“, the central syllable “aib”, and the suffix “-ol” to
designate its peptide structure, the presence of an a-aminoisobutyryl unit,
and the C-terminal alcohol.
ALAMETHICIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ALAMETHICIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 51)Lieferanten
59588-86-2()Verwandte Suche:
- alamethicinf30
- alamethicingamma
- alamethicini
- f-50
- U-22324
- ANTIBIOTIC U-22324
- ALMETHICIN
- ALAMETHACIN
- ALAMETHICIN
- 59588-86-2
- BioChemical
- Antibiotics
- Antibiotics A-F
- Antibiotics A to Z
