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HC TOXIN

HC TOXIN Struktur
83209-65-8
CAS-Nr.
83209-65-8
Englisch Name:
HC TOXIN
Synonyma:
Toxin I;HC TOXIN;HC toxin I;Cyclo(aoe-Pro-Ala-ala);HC TOXIN FROM HELMINTHOSPORIUM CARBONUM;HC Toxin, histone deacetylase (HDAC) inhibitor;HC toxin from Helminthosporium carbonum;Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-];CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID);Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
CBNumber:
CB2460604
Summenformel:
C21H32N4O6
Molgewicht:
436.51
MOL-Datei:
83209-65-8.mol

HC TOXIN Eigenschaften

Siedepunkt:
819.2±65.0 °C(Predicted)
Dichte
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: 10 mg/ml; Methanol: 10 mg/ml
pka
13.33±0.70(Predicted)
Aggregatzustand
lyophilized powder
Farbe
Off-white to light yellow
InChI
1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)
InChIKey
GNYCTMYOHGBSBI-UHFFFAOYSA-N
SMILES
CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C3CO3)NC1=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
Speicherklasse 6.1B - Non-combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Oral
Bildanzeige (GHS) Skull and Crossbones (GHS06)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizit?t oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

HC TOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Verwenden

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

HC TOXIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


HC TOXIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 69)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860
anhua.mao@aladdin-e.com China 29974 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4784 55
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51395 80
Shanghai YuanYe Biotechnology Co., Ltd. 13636370518
shyysw007@163.com China 89686 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58
BOC Sciences --
info@bocsci.com USA 0 65

83209-65-8()Verwandte Suche:


  • HC TOXIN FROM HELMINTHOSPORIUM CARBONUM
  • Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-]
  • Cyclo[L-Ala-D-Ala-[(2S)-2-amino*-8-oxo-8-oxiranyloctanoyl]-D-Pro-]
  • HC toxin I
  • Toxin I
  • Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)
  • Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
  • Cyclo(aoe-Pro-Ala-ala)
  • Cyclo(L-alanyl-D-alanyl-(alphas,2S)-alpha-amino-eta-oxooxiraneoctanoyl-D-prolyl)
  • Cyclo(L-alanyl-D-alanyl-8-oxiranyl-8-oxo-L-2-aminooctanoyl-D-prolyl), (S)-
  • CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID)
  • HC TOXIN
  • (3S,6R,9S,12R)-6,9-dimethyl-3-[6-[(2S)-oxiran-2-yl]-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
  • HC Toxin, histone deacetylase (HDAC) inhibitor
  • HC toxin from Helminthosporium carbonum
  • 83209-65-8
  • C21H32N4O6
  • Cell Signaling and Neuroscience
  • Mold
  • Toxins and Venoms
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